Page 58 - TD-4-2

Tumor Discovery Role of honokiol in combination therapy

Visualization: Laxminarayan Rawat, Raghu Solanki, Rahul 9. Sabarwal A, Kumar K, Shyanti R, Singh RP. Curcumin in
Kumar cancer prevention. In: Functional Food and Human Health.
Writing – original draft: Laxminarayan Rawat Berlin, Germany: Springer; 2018. p. 329-374.
Writing – review & editing: Soumitro Pal, Akash Sabarwal doi: 10.1007/978-981-13-1123-9_16
Ethics approval and consent to participate 10. Rawat L, Nayak V. Piperlongumine induces ROS mediated
apoptosis by transcriptional regulation of SMAD4/P21/P53
Not applicable genes and synergizes with doxorubicin in osteosarcoma
cells. Chem Biol Interact. 2022;354:109832.
Consent for publication
doi: 10.1016/J.CBI.2022.109832
Not applicable.
11. Rawat L, Nayak V. Ursolic acid disturbs ROS homeostasis
Availability of data and regulates survival-associated gene expression to induce
apoptosis in intestinal cancer cells. Toxicol Res (Camb).
Data sharing does not apply to this article as no new data 2021;10(3):369-375.
were created or analyzed in this study. doi: 10.1093/toxres/tfab025

References 12. Rawat L, Hegde H, Hoti SL, Nayak V. Piperlongumine
induces ROS mediated cell death and synergizes paclitaxel
1. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics in human intestinal cancer cells. Biomed Pharmacother.
2020: GLOBOCAN estimates of incidence and mortality 2020;128:110243.
worldwide for 36 cancers in 185 countries. CA Cancer J Clin.
2021;71(3):209-249. doi: 10.1016/j.biopha.2020.110243
doi: 10.3322/CAAC.21660 13. Yao Y, Habib M, Bajwa HF, et al. Herbal therapies in
gastrointestinal and hepatic disorders: An evidence-based
2. Zugazagoitia J, Guedes C, Ponce S, Ferrer I, Molina-Pinelo S,
Paz-Ares L. Current challenges in cancer treatment. Clin clinical review. Front Pharmacol. 2022;13:962095.
Ther. 2016;38(7):1551-1566. doi: 10.3389/FPHAR.2022.962095
doi: 10.1016/J.CLINTHERA.2016.03.026 14. Jha NK, Arfin S, Jha SK, et al. Re-establishing the
3. Greaves M. Evolutionary determinants of cancer. Cancer comprehension of phytomedicine and nanomedicine in
Discov. 2015;5(8):806-821. inflammation-mediated cancer signaling. Semin Cancer
Biol. 2022;86:1086-1104.
doi: 10.1158/2159-8290.CD-15-0439
doi: 10.1016/J.SEMCANCER.2022.02.022
4. Greaves M, Maley CC. Clonal evolution in cancer. Nature.
2012;481(7381):306-313. 15. Alonso-Castro AJ, Zapata-Bustos R, Domínguez F,
García-Carrancá A, Salazar-Olivo LA. Magnolia dealbata
doi: 10.1038/nature10762 Zucc and its active principles honokiol and magnolol
5. Regad T. Targeting RTK signaling pathways in cancer. stimulate glucose uptake in murine and human adipocytes
Cancers (Basel). 2015;7(3):1758-1784. using the insulin-signaling pathway. Phytomedicine.
2011;18(11):926-933.
doi: 10.3390/cancers7030860
doi: 10.1016/J.PHYMED.2011.02.015
6. Wang X, Zhang H, Chen X. Drug resistance and
combating drug resistance in cancer. Cancer Drug Resist. 16. Rauf A, Patel S, Imran M, et al. Honokiol: An anticancer
2019;2(2):141-160. lignan. Biomed Pharmacother. 2018;107:555-562.
doi: 10.20517/CDR.2019.10 doi: 10.1016/J.BIOPHA.2018.08.054
7. Leary M, Heerboth S, Lapinska K, Sarkar S. Sensitization of 17. Rauf A, Olatunde A, Imran M, et al. Honokiol: A review
drug resistant cancer cells: A matter of combination therapy. of its pharmacological potential and therapeutic insights.
Cancers (Basel). 2018;10(12):483. Phytomedicine. 2021;90:153647.
doi: 10.3390/CANCERS10120483 doi: 10.1016/J.PHYMED.2021.153647
8. Sabarwal A, Agarwal R, Singh RP. Fisetin inhibits cellular 18. Solanki R, Rawat L, Tabasum S, Pal S, Patel S, Sabarwal A.
proliferation and induces mitochondria-dependent A comprehensive review of anti-cancer mechanisms of
apoptosis in human gastric cancer cells. Mol Carcinog. polyphenol honokiol and nano carrier-based approaches to
2017;56(2):499-514. enhance its therapeutic potential. Phytochem Rev. 2025:1-27.
doi: 10.1002/MC.22512 doi: 10.1007/S11101-025-10090-0

Volume 4 Issue 2 (2025) 50 doi: 10.36922/td.8152