Page 59 - TD-4-2
P. 59
Tumor Discovery Role of honokiol in combination therapy
19. Eliaz I, Weil E. Intravenous honokiol in drug-resistant honokiol in oral carcinoma stem cells via regulation of IL-6/
cancer: Two case reports. Integr Cancer Ther. 2020;19:1-5. Stat3 signaling. Environ Toxicol. 2018;33(11):1105-1112.
doi: 10.1177/1534735420922615 doi: 10.1002/TOX.22587
20. Ong CP, Lee WL, Tang YQ, Yap WH. Honokiol: A review 31. Qi M, Chen X, Bian L, Zhang H, Ma J. Honokiol combined
of its anticancer potential and mechanisms. Cancers (Basel). with curcumin sensitizes multidrug-resistant human lung
2019;12(1):48. adenocarcinoma A549/DDP cells to cisplatin. Exp Ther
doi: 10.3390/CANCERS12010048 Med. 2021;22(5):1301.
21. Saunders RN, Metcalfe MS, Nicholson ML. Rapamycin doi: 10.3892/ETM.2021.10736
in transplantation: A review of the evidence. Kidney Int. 32. Wang TEJ, Liu HT, Lai YH, et al. Honokiol, a polyphenol
2001;59(1):3-16. natural compound, attenuates cisplatin-induced acute
doi: 10.1046/J.1523-1755.2001.00460.X cytotoxicity in renal epithelial cells through cellular oxidative
stress and cytoskeleton modulations. Front Pharmacol.
22. Laupacis A, Keown PA, Ulan RA, McKenzie N, Stiller CR. 2018;9(APR):357.
Cyclosporin A: A powerful immunosuppressant. Can Med
Assoc J. 1982;126(9):1041-1046. doi: 10.3389/FPHAR.2018.00357
23. Jiang QQ, Fan LY, Yang GL, et al. Improved therapeutic 33. Mao RW, He SP, Lan JG, Zhu WZ. Honokiol
effectiveness by combining liposomal honokiol with ameliorates cisplatin-induced acute kidney injury via
cisplatin in lung cancer model. BMC Cancer. 2008;8(1):242. inhibition of mitochondrial fission. Br J Pharmacol.
2022;179(14):3886-3904.
doi: 10.1186/1471-2407-8-242
doi: 10.1111/BPH.15837
24. Liu H, Zang C, Emde A, et al. Anti-tumor effect of honokiol
alone and in combination with other anti-cancer agents in 34. Li M, Li CM, Ye ZC, et al. Sirt3 modulates fatty acid
breast cancer. Eur J Pharmacol. 2008;591(1-3):43-51. oxidation and attenuates cisplatin-induced AKI in mice.
J Cell Mol Med. 2020;24(9):5109-5121.
doi: 10.1016/J.EJPHAR.2008.06.026
doi: 10.1111/JCMM.15148
25. Huang KJ, Kuo CH, Chen SH, Lin CY, Lee YR. Honokiol
inhibits in vitro and in vivo growth of oral squamous cell 35. Weaver BA. How taxol/paclitaxel kills cancer cells. Mol Biol
carcinoma through induction of apoptosis, cell cycle arrest Cell. 2014;25(18):2677-2681.
and autophagy. J Cell Mol Med. 2018;22(3):1894-1908. doi: 10.1091/MBC.E14-04-0916
doi: 10.1111/JCMM.13474 36. Wang X, Beitler JJ, Wang H, et al. Honokiol enhances
26. Sabarwal A, Chakraborty S, Mahanta S, Banerjee S, Balan M, paclitaxel efficacy in multi-drug resistant human cancer
Pal S. A novel combination treatment with honokiol and model through the induction of apoptosis. PLoS One.
rapamycin effectively restricts c-met-induced growth of 2014;9(2):e86369.
renal cancer cells, and also inhibits the expression of tumor doi: 10.1371/JOURNAL.PONE.0086369
cell PD-L1 involved in immune escape. Cancers (Basel).
2020;12(7):1782. 37. Li XQ, Ren J, Wang Y, et al. Synergistic killing effect of
paclitaxel and honokiol in non-small cell lung cancer
doi: 10.3390/CANCERS12071782 cells through paraptosis induction. Cell Oncol (Dordr).
27. Romani AMP. Cisplatin in cancer treatment. Biochem 2021;44(1):135-150.
Pharmacol. 2022;206:115323. doi: 10.1007/S13402-020-00557-x
doi: 10.1016/J.BCP.2022.115323 38. Wang X, Cheng L, Xie HJ, et al. Functional paclitaxel
28. Cheng N, Xia T, Han Y, He QJ, Zhao R, Ma JR. Synergistic plus honokiol micelles destroying tumour metastasis in
antitumor effects of liposomal honokiol combined treatment of non-small-cell lung cancer. Artif Cells Nanomed
with cisplatin in colon cancer models. Oncol Lett. Biotechnol. 2018;46(sup2):1154-1169.
2011;2(5):957-962. doi: 10.1080/21691401.2018.1481082
doi: 10.3892/OL.2011.350 39. Wang Z, Li X, Wang D, et al. Concurrently suppressing
29. Liu Y, Chen L, He X, et al. Enhancement of therapeutic multidrug resistance and metastasis of breast cancer by
effectiveness by combining liposomal honokiol with co-delivery of paclitaxel and honokiol with pH-sensitive
cisplatin in ovarian carcinoma. Int J Gynecol Cancer. polymeric micelles. Acta Biomater. 2017;62:144-156.
2008;18(4):652-659.
doi: 10.1016/J.ACTBIO.2017.08.027
doi: 10.1136/IJGC-00009577-200807000-00009
40. Lu X, Lu X, Yang P, Zhang Z, Lv H. Honokiol nanosuspensions
30. Chang MT, Lee SP, Fang CY, et al. Chemosensitizing effect of loaded thermosensitive hydrogels as the local delivery system
Volume 4 Issue 2 (2025) 51 doi: 10.36922/td.8152

