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inflammation.  Considering  the  biocompatibility,  biodegradability,  and  performance  efficacy

               against  the  LPS-induced  OA,  the  designed  osteochondral  model  using  microfluidics  and


               bioprinting technologies is promising for screening OA therapeutics.


























































               Figure 9. Bioprinting of microtissue bioinks. (A) Schematic diagram of OA model constructed and

               drug screening. The influence of (B) TNF-α, (C) IL-1β, (D) IL-6 and (E) IL-10 contents by drug


               treatment (n=3, *P<0.05, **P<0.01, ***P<0.001).







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