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effective drug
concentration and
pharmacokinetic
profiles.
Using 3D bioprinting to
fabricate liver cancer cell
88
clusters and microfluidic Metuzumab Li et al.
chips for cellular
maintenance ·Reduced model preparation ·Insufficient
Developing a device to Different workload precision in 3D cell
60
sustain patient-derived chemotherapie ·Higher cell proliferation printing (still Steinberg et al.
multicellular spheroids s efficiency requires bioink-
3D ·Streamlining the cycle of assisted
printing Using a device to culture designing, prototyping, and testing perfusion)(limiting Gallegos-Martínez
cancer cells or spheroids DOX new microfluidic devices the physiological et al.
36
embedded in hydrogels ·Significant reduction in post- accuracy of
processing time and cost vascularized models)
Assessing tumor New pyrazino
spheroid formation [1,2-a] User-friendly ·Inadequate Rahimifard et al.
87
ability benzimidazole ·Environmental-friendly biocompatibility
derivatives (compared to PMMA) (SLA resin)
Fabricating a perfusion Various drug ·Limited optical
61
cell culture device transparency (SLA Ong et al.
resin)

62