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Abstract
Diabetic wound healing disorder was one of the common complications in diabetic

patients, which was characterized by persistent chronic inflammation, impaired

angiogenesis, abnormal remodeling of extracellular matrix (ECM), and significantly

increased oxidative stress level. Although the traditional treatment models have achieved

some success, it still faced the challenges of prolonged wound healing time, increased risk

of infection, and continuous formation of scar tissue, especially in gastrointestinal surgical

incisions, orthopedic surgical incisions, and neurosurgical surgical incisions. In recent

years, the integration of biomaterials and advanced manufacturing technologies brought

new opportunities for diabetic wound repair. Hydrogels have gained more attention due to

the excellent biocompatibility, degradability, and significant wound repair ability. As an

emerging advanced manufacturing method, 3D printing technology could accurately

fabricate hydrogels according to the shape and size of the wound, providing an ideal

microenvironment for wound repair. In this review, we systematically reviewed the latest
research of 3D printed hydrogels in diabetic wound repair in the past five years, and deeply

discussed the preparation methods, including physical, chemical, and biological cross-
linking methods, and the specific mechanisms of promoting wound healing, such as

regulating inflammatory response, promoting angiogenesis, and guiding the normal

remodeling of ECM. This review aimed to provide a solid theoretical and experimental

basis for the continued development and eventual clinical application of 3D printed

hydrogels for diabetic wounds.

Keywords: 3D printed hydrogel; Surgical incision; Diabetic wound; Preparation method;

Mechanism

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