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activity and thereby expediting the wound healing process. [21]24 However, traditional

hydrogels still exhibited certain limitations, including insufficient mechanical strength,
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uncontrollable pore structures, and uneven release of antibacterial components. As
bio-manufacturing technology advances rapidly, 3D printing has broken through

traditional hydrogel preparation limits, achieving an upgrade from structural

biomimicry to functional integration and providing smarter, personalized solutions for

diabetic wound repair. For instance, through precise adjustment of printing parameters

and material composition, it was possible to optimize the moisturizing and breathable

characteristics of the dressing, while also enabling the accurate incorporation of

antibacterial agents. And its layer-by-layer manufacturing ability enabled the

construction of the biomimetic gradient structure to mimic the mechanical properties

of natural tissue, which further improved the adaptability of dressings to wounds. Thus,

this modern dressing with multifunctional and optimized design was of great

significance for making up for the defects of traditional dressings, accelerating wound

healing, improving the prognosis of patients, and shortening the rehabilitation cycle.

In view of the unique advantages and great potential of 3D printed hydrogels in
the field of diabetic wound repair, it was of great scientific and clinical significance to

explore its preparation methods and mechanisms of action. Therefore, this review has

systematically summarized the research progress of 3D printed hydrogels in the past

five years, aiming to provide a solid theoretical basis and technical support for the

development of a new generation of smart wound dressings that are used to repair the

diabetic wound.

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