Page 15 - AN-1-1

Advanced Neurology AIS in patients with COVID-19

Table 2. Characteristics and outcomes of acute ischemic stroke patients with COVID-19 versus those without COVID-19.
Variables No. of AIS patients AIS patients OR (95% CI) OR (95% CI) P I 2 heterogeeneity % P heterogeeneity
studies with without or pooled MD or pooled MD
COVID-19 COVID-19 Random effects Fixed effects
Demographics
Age a 20 3962 26897 −2.31 (−3.88, −0.75) −0.91 0.004** 64 < 0.0001***
(−1.43, −0.38)
Gender (male) 23 2350/4154 36522/70867 1.29 (1.09, 1.54) 1.20 (1.13, 1.28) 0.004** 60 0.0001***
Stroke subtype (TOAST)
Small vessel 13 62/564 579/3402 0.64 (0.38, 1.08) 0.65 (0.49, 0.87) 0.10 59 0.004**
Large artery 12 96/542 645/3354 0.91 (0.67, 1.24) 0.90 (0.70, 1.16) 0.56 24 0.21
atherosclerosis
Cardioembolic 12 151/542 939/3354 1.01 (0.82, 1.26) 1.00 (0.81, 1.24) 0.91 0 0.58
Other known 11 23/470 100/2198 1.11 (0.58, 2.13) 0.99 (0.62, 1.58) 0.75 32 0.14
cause
Cryptogenic 11 199/470 654/2198 1.83 (1.24, 2.70) 1.69 (1.36, 2.10) 0.002** 62 0.003**
Stroke territories
Anterior 7 146/168 675/913 2.29 (1.03, 5.10) 2.97 (1.77, 4.98) 0.04* 37 0.15
circulation
MCA 9 118/281 421/946 0.79 (0.42, 1.50) 0.87 (0.65, 1.18) 0.48 72 0.0004***
ICA 7 47/229 88/736 1.85 (1.19, 2.88) 1.88 (1.22, 2.90) 0.007* 0 0.73
Posterior 7 12/168 155/913 0.42 (0.19, 0.95) 0.32 (0.17, 0.59) 0.04* 28 0.21
circulation
Multiple 4 37/167 86/930 2.64 (1.62, 4.29) 2.68 (1.66, 4.32) < 0.0001*** 0 0.39
territories
Laboratory findings
CRP, mg/L a 6 310 2120 55.90 (33.32, 78.49) 47.29 (36.16, < 0.00001*** 67 0.009*
58.42)
3
WBC, ×10 /µL a 8 316 1772 0.21 (−0.46, 0.88) 0.19 (−0.20, 0.59) 0.54 42 0.10
APTT b 7 316 1937 0.33 (0.02, 0.64) 0.40 (0.28, 0.52) 0.04* 82 < 0.00001***
PT b 6 214 1236 0.41 (0.04, 0.79) 0.44 (0.29, 0.59) 0.03* 79 0.0003***
PLT, ×10 /µL a 9 397 2945 14.78 (−5.31, 34.87) 7.46 (−3.19, 18.12) 0.15 62 0.008*
3
D-dimer b 5 195 1082 0.81 (0.52, 1.10) 0.84 (0.68, 1.00) < 0.00001*** 59 0.04*
Other stroke characteristics
NIHSS at 17 1697 45017 3.21 (2.13, 4.29) 3.79 (3.33, 4.25) < 0.00001*** 64 0.0002***
admission a
Large vessel 8 437/1428 9358/42561 1.68 (1.10, 2.57) 1.41 (1.25, 1.59) 0.02* 75 0.0002***
occlusion
Volume of 2 31 115 33.30 (−12.44, 79.04) 20.27 (4.45, 36.10) 0.15 75 0.04*
infarction, cm3 a
ASPECT score a 5 88 829 −0.22 (−1.31, 0.87) 0.29 (−0.19, 0.78) 0.69 74 0.004**
Overall outcomes of AIS
HT 6 130/2392 1074/23226 1.34 (0.91, 1.98) 1.11 (0.92, 1.35) 0.14 39 0.15
sICH 6 15/190 79/1245 1.46 (0.81, 2.62) 1.40 (0.78, 2.49) 0.21 0 0.55
In-hospital 19 659/2871 2290/29187 3.70 (2.73, 5.02) 3.46 (3.13, 3.82) < 0.00001*** 64 < 0.0001***
mortality
Favorable 10 136/415 2811/5250 0.49 (0.39, 0.61) 0.49 (0.39, 0.61) < 0.00001*** 0 0.93
discharge
(Contd...)

Volume 1 Issue 1 (2022) 7 https://doi.org/10.36922/an.v1i1.28