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Advanced Neurology

ORIGINAL RESEARCH ARTICLE
Decreased cortical thickness and normal

regional homogeneity underlying cognitive
impairment in cerebral small vessel disease

Yuting Mo 1,2,3† , Lili Huang 1,2,3† , Ruomeng Qin 1,2,3 , Kelei He , Zhihong Ke 1,2,3 ,
4
5
5
Zheqi Hu 1,2,3 , Chenglu Mao 1,2,3 , Biyun Xu , Ruowen Qi , Xiaolei Zhu 1,2,3 *,
and Qing Ye 1,2,3 *
1 Department of Neurology of Drum Tower Hospital, Medical School and the State Key Laboratory of
Pharmaceutical Biotechnology, Nanjing University, Nanjing 210008, China
2 Nanjing Neurology Clinic Medical Center, Nanjing 210008, China
3 Institute of Brain Science, Nanjing University, Nanjing 210008, China
4 National Institute of Healthcare Data Science at Nanjing University, China
5 Medical Statistics and Analysis Center, Nanjing Drum Tower Hospital, Nanjing University Medical
School, 321 Zhongshan Road, Nanjing, 210008, China

Abstract

Cerebral small vessel disease (CSVD) is the most common cause of vascular
cognitive impairment (CI). However, the cognitive performance of individuals
† These authors contributed equally
to this work with CSVD varies considerably. Early identification of neuroimaging changes
*Corresponding authors: related to CI caused by CSVD is important for the prediction and management of
Qing Ye (yeqingyouxiang@126.com) CI. The present study aimed to explore the early alterations in cortical thickness
Xiaolei Zhu (zhuquelee@126.com) and regional homogeneity (ReHo) related to CI in people with CSVD. A total of
Citation: Mo Y, Huang L, Qin R, 106 participants with CSVD with CI, 77 participants with CSVD without CI, and 121
et al., 2022, Decreased cortical control participants underwent neuropsychological tests and multimodal magnetic
thickness and normal regional resonance imaging scans. Cortical thickness was analyzed using FreeSurfer software,
homogeneity underlying cognitive
impairment in cerebral small vessel and ReHo patterns were explored using the DPARSF toolbox in brain regions that
disease. Adv Neuro, 1(1): 48. exhibited alterations in cortical thickness. The CSVD with CI group exhibited
https://doi.org/10.36922/an.v1i1.48 decreased cortical thickness but normal ReHo in the right anterior cingulate gyrus
Received: November 16, 2021 (ACG), right cuneus, bilateral insula, and right middle temporal gyrus compared
Accepted: March 14, 2022 with that in the other two groups. Specifically, both cortical thickness and ReHo
in the right ACG were significantly associated with memory performance in CSVD
Published Online: March 30, 2022 patients with CI. In addition, impaired visuospatial function occurred earlier than
Copyright: © 2022 Author(s). the decline of global function in CSVD patients and was related to cortical thinning
This is an Open Access article in the right middle temporal gyrus. In conclusion, decreased cortical thickness
distributed under the terms of the
Creative Commons Attribution but normal ReHo in the right ACG, right cuneus, bilateral insula, and right middle
License, permitting distribution, temporal gyrus are characteristic alterations related to the development of CI in
and reproduction in any medium, CSVD patients. These findings may contribute to the early prediction of CI in CSVD
provided the original work is
properly cited. patients.
Publisher’s Note: AccScience
Publishing remains neutral with Keywords: Cerebral small vessel disease; Cognitive impairment; Cortical thickness;
regard to jurisdictional claims in
published maps and institutional Regional homogeneity
affiliations.

Volume 1 Issue 1 (2022) 1 https://doi.org/10.36922/an.v1i1.48