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Advanced Neurology Cortical thickness and regional homogeneity in CSVD

Table 2. Results of clinical assessments
CSVD‑CI group CSVD‑no‑CI group NC group Statistics P‑value
(n=106) (n=77) (n=121)
Demographics
Sex
Male 61 (57.55) 48 (62.34) 67 (55.37) 0.945 0.624 a
Female 45 (42.45) 29 (37.66) 54 (44.63)
Age (years, mean±s.d.) 66.00±8.25 65.68±9.45 60.52±7.76 14.686 <0.001 b
Education (years) d 9.00 (9.00–12.00) 12.00 (9.00–15.00) 12.00 (9.00–15.00) 7.531 0.023 c
Vascular risk factors
Hypertension, n (%) 64 (60.38) 56 (72.73) 64 (52.89) 7.750 0.021 a
Diabetes, n (%) 21 (19.81) 23 (29.87) 21 (17.36) 4.623 0.099 a
Hyperlipidemia, n (%) 23 (21.70) 16 (20.78) 23 (19.01) 0.261 0.878 a
Smoking, n (%) 16 (15.09) 14 (18.18) 16 (13.22) 0.901 0.637 a
Fazekas scores d 2.00 (2.00–3.00) 2.00 (2.00–3.00) 1.00 (1.00–1.00) 157.302 <0.001 c
Lacunar infarcts count d 2.00 (1.00–4.25) 1.00 (0.00–3.50) 0.00 (0.00–0.00) 148.070 <0.001 c
Microbleeds d 1.00 (0.00–3.00) 1.00 (0.00–3.00) 0.00 (0.00–0.00) 66.865 <0.001 c
Neuropsychological data
HAMD d 6.00 (3.00–9.00) 3.00 (1.00–7.00) 5.00 (2.00–9.00) 9.294 0.010 c
HAMA d 7.00 (3.00–12.00) 5.00 (1.00–11.00) 6.00 (3.00–13.25) 3.072 0.215 c
MoCA d 21.00 (18.00–23.00) 26.00 (25.00–27.00) 27.00 (25.00–28.00) 154.356 <0.001 c
VRC d 14.00 (13.00–14.00) 14.00 (14.00–14.00) 14.00 (14.00–14.00) 13.999 0.001 c
VRIR d 8.00 (5.00–10.00) 10.00 (7.00–12.00) 11.00 (9.00–13.00) 38.384 <0.001 c
VRDR d 5.00 (3.00–9.00) 8.00 (5.00–11.00) 9.50 (6.00–12.00) 22.957 <0.001 c
AVLTIR d 12.00 (10.00–16.00) 15.00 (13.00–18.00) 17.00 (14.00–20.00) 35.777 <0.001 c
AVLTSTDR (mean±s.d.) 3.44±2.37 5.15±2.38 5.71±2.11 22.467 <0.001 b
AVLTLTDR (mean±s.d.) 3.06±2.17 5.00±2.18 5.38±2.16 26.622 <0.001 b
DSF d 8.00 (7.00–8.00) 8.00 (7.50–9.00) 8.00 (8.00–9.00) 15.176 0.001 c
DSB d 4.00 (3.00–5.00) 5.00 (4.00–6.00) 5.00 (4.00–6.00) 19.107 <0.001 c
SCWT – congruent part d 23.50 (18.00–30.25) 16.00 (14.00–22.00) 17.00 (14.00–20.50) 45.707 <0.001 c
SCWT – incongruent 12.00 (4.25–20.00) 11.00 (5.00–20.25) 11.00 (5.50–17.00) 0.380 0.827 c
part d
BNT d 48.00 (40.00–52.50) 52.00 (48.00–55.25) 54.00 (49.25–56.75) 29.620 <0.001 c
s.d.: Standard deviation, : P value of Chi-squared test, : P value of ANOVA, : P value of Kruskal–Wallis test, : Data with non-normal distribution were
c
d
b
a
described by median (interquartile range)
In general, the CSVD with CI group displayed extensive cortical thinning than those without CI . In the
[34]
decreased cortical thickness in five regions, including present study, the contribution of cortical thinning in the
the right ACG, right cuneus, bilateral insula, and right right ACG to CI in CSVD patients has been reported for
st
MTG, whereas the CSVD without CI group only exhibited the 1 time.
decreased cortical thickness in the latter three regions. This In addition, the ReHo analysis showed that the CSVD
suggests that cortical thinning in bilateral insula and right without CI group exhibited decreased ReHo values in
MTG is related to the development of CSVD, and cortical bilateral insula, whereas the CSVD with CI group showed
thinning in the right ACG and right cuneus is related to no changes in ReHo values compared with the NC group.
the development of CI in these patients. Similarly, cortical One previous study revealed no significant difference in
thinning in the bilateral insula, right cuneus, and right ReHo between patients with lacunar infarctions and mild
MTG has been reported in subcortical ischemic vascular CI and NC participants . On the basis of the present
[35]
disease patients and patients with CI showed more findings, we speculate that cortical thinning in the five

Volume 1 Issue 1 (2022) 6 https://doi.org/10.36922/an.v1i1.48