Page 14 - AN-1-2
P. 14
Advanced Neurology Pantothenic acid in kainic acid-induced epilepsy
Acknowledgments 8. Kim DH, Kim DW, Jung BH, et al., 2019, Ginsenoside
Rb2 suppresses the glutamate-mediated oxidative stress
The authors want to thank all the institutes affiliated to this and neuronal cell death in HT22 cells. J Ginseng Res,
study for providing necessary research facilities. 43(2): 326–334.
Funding 9. Chen J, Quan QY, Yang F, et al., 2010, Effects of lamotrigine and
topiramate on hippocampal neurogenesis in experimental
This research study was funded by the institutional funding. temporal-lobe epilepsy. Brain Res, 1313: 270–282.
Conflict of interest https://doi.org/10.1016/j.brainres.2009.12.024
10. Golechha M, Chaudhry U, Bhatia J, et al., 2011, Naringin
The authors have no conflict of interest to declare.
protects against kainic acid-induced status epilepticus
Author contributions in rats: Evidence for an antioxidant, anti-inflammatory
and neuroprotective intervention. Biol Pharm Bull,
Conceptualization: Souravh Bais 34(3): 360–365.
Investigation: Renu Kumari Rana https://doi.org/10.1248/bpb.34.360
Formal analysis: Nirmal Dongre, Aakash Singh Panwar,
Gaurav Goyanar 11. Milatovic D, Gupta RC, 2019, Antioxidants in prevention
Writing – original draft: Alok Kumar Soni and treatment of diseases and toxicity. In: Nutraceuticals in
Veterinary Medicine. Berlin: Springer, Cham. pp. 205–213.
Writing – review & editing: Souravh Bais, Shanti Lal
Singune 12. Silva B, Oliveira PJ, Dias A, et al., 2008, Quercetin,
kaempferol and biapigenin from Hypericum perforatum are
References neuroprotective against excitotoxic insults. Neurotox Res,
13(3-4): 265–279.
1. Baxendale S, Heaney D, 2021, Memory complaints in the
epilepsy clinic. Pract Neurology, 21(1): 25–29. https://doi.org/10.1007/BF03033510
https://doi.org/10.1136/practneurol-2020-002523 13. Patassini S, Begley P, Xu J, et al., 2019, Cerebral vitamin
B5 (D-pantothenic acid) deficiency as a potential cause
2. Packer RM, McGreevy PD, Salvin HE, et al., 2018, Cognitive of metabolic perturbation and neurodegeneration in
dysfunction in naturally occurring canine idiopathic Huntington’s disease. Metabolites, 9(6): 113.
epilepsy. PLoS One, 13(2): e0192182.
https://doi.org/10.3390/metabo9060113
https://doi.org/10.1371/journal.pone.0192182
14. Wu Z, Xu Q, Zhang L, et al., 2009, Protective effect of
3. Garthwaite J, 2019, NO as a multimodal transmitter in the resveratrol against kainate-induced temporal lobe epilepsy
brain: Discovery and current status. Br J Pharmacol, 176(2): in rats. Neurochem Res, 34(8): 1393–1400.
197–211.
https://doi.org/10.1007/s11064-009-9920-0
https://doi.org/10.1111/bph.14532
15. Binvignat O, Olloquequi J, 2020, Excitotoxicity as a target
4. Postnikova TY, Zubareva OE, Kovalenko AA, et al., against neurodegenerative processes. Curr Pharm Des,
2017, Status epilepticus impairs synaptic plasticity in rat 26(12): 1251–1262.
hippocampus and is followed by changes in expression of
NMDA receptors. Biochemistry (Mosc), 82(3): 282–290. https://doi.org/10.2174/1381612826666200113162641
https://doi.org/10.1134/S0006297917030063 16. Paudel YN, Shaikh MF, Shah S, et al., 2018, Role
of inflammation in epilepsy and neurobehavioral
5. Wang X, Zhang Y, Cheng W, et al., 2021, Decreased comorbidities: Implication for therapy. Eur J Pharmacol,
excitatory drive onto hilar neuronal nitric oxide synthase 837: 145–155.
expressing interneurons in chronic models of epilepsy. Brain
Res, 1764: 147467. https://doi.org/10.1016/j.ejphar.2018.08.020
https://doi.org/10.1016/j.brainres.2021.147467 17. Rana A, Musto AE, 2018, The role of inflammation in the
development of epilepsy. J Neuroinflammation, 15(1): 144.
6. Gupta YK, Briyal S, Sharma M, 2009, Protective effect of
curcumin against kainic acid induced seizures and oxidative https://doi.org/10.1186/s12974-018-1192-7
stress in rats. Indian J Physiol Pharmacol, 53(1): 39–46. 18. Stubley-Weatherly L, Harding JW, Wright JW, 1996, Effects
7. Lin TK, Chen SD, Lin KJ, et al., 2020, Seizure-induced of discrete kainic acid-induced hippocampal lesions on
oxidative stress in status epilepticus: Is antioxidant spatial and contextual learning and memory in rats. Brain
beneficial? Antioxidants, 9(11): 1029. Res, 716(1-2): 29–38.
https://doi.org/10.3390/antiox9111029 19. Nugroho A, Park JH, Choi JS, et al., 2019, Structure
Volume 1 Issue 2 (2022) 8 https://doi.org/10.36922/an.v1i2.40

