Page 85 - AN-1-3

Advanced Neurology Microglia in autism spectrum disorder

https://doi.org/10.1038/s41593-020-00762-9 disorder. Transl Psychiatry, 12(1): 228.
12. Jensen AR, Lane AL, Werner BA, et al., 2022, Modern https://doi.org/10.1038/s41398-022-01987-x
biomarkers for autism spectrum disorder: Future directions. 24. Koyama R, Ikegaya Y, 2015, Microglia in the pathogenesis of
Mol Diagn Ther, 26(5): 483–495.
autism spectrum disorders. Neurosci Res, 100: 1–5.
https://doi.org/10.1007/s40291-022-00600-7
https://doi.org/10.1016/j.neures.2015.06.005
13. Seiffe A, Ramirez MF, Sempe L, et al., 2022, Juvenile 25. Won H, Lee HR, Gee HY, et al., 2012, Autistic-like social
handling rescues autism-related effects of prenatal exposure behaviour in Shank2-mutant mice improved by restoring
to valproic acid. Sci Rep, 12(1): 7174.
NMDA receptor function. Nature, 486(7402): 261–265.
https://doi.org/10.1038/s41598-022-11269-7
https://doi.org/10.1038/nature11208
14. De Luca SN, Soch A, Sominsky L, et al., 2020, Glial 26. Chao HT, Chen H, Samaco RC, et al., 2010, Dysfunction in
remodeling enhances short-term memory performance in GABA signalling mediates autism-like stereotypies and Rett
Wistar rats. J Neuroinflammation, 17(1): 52.
syndrome phenotypes. Nature, 468(7321): 263–269.
https://doi.org/10.1186/s12974-020-1729-4
https://doi.org/10.1038/nature09582
15. Barahona RA, Morabito S, Swarup V, et al., 2022, Cortical 27. Colonna M, Butovsky O, 2017, Microglia function in the
diurnal rhythms remain intact with microglial depletion. Sci central nervous system during health and neurodegeneration.
Rep, 12(1): 114.
Annu Rev Immunol, 35: 441–468.
https://doi.org/10.1038/s41598-021-04079-w
https://doi.org/10.1146/annurev-immunol-051116-052358
16. Choudhury ME, Miyanishi K, Takeda H, et al., 2020, 28. Sanjay, Park M, Lee HJ, 2022, Roles of fatty acids in
Phagocytic elimination of synapses by microglia during microglial polarization: Evidence from in vitro and in vivo
sleep. Glia, 68(1): 44–59.
studies on neurodegenerative diseases. Int J Mol Sci, 23(13):
https://doi.org/10.1002/glia.23698 7300.
17. Jin X, Simmons SK, Guo A, et al., 2020, In vivo perturb-seq https://doi.org/10.3390/ijms23137300
reveals neuronal and glial abnormalities associated with 29. Gilchrist SE, Pennelli GM, Hafizi S, 2021, Gas6/TAM
autism risk genes. Science, 370(6520): eaaz6063.
signalling negatively regulates inflammatory induction of
https://doi.org/10.1126/science.aaz6063 GM-CSF in mouse brain microglia. Cells, 10(12): 3281.
18. Vargas DL, Nascimbene C, Krishnan C, et al., 2005, https://doi.org/10.3390/cells10123281
Neuroglial activation and neuroinflammation in the brain 30. Hyder U, Mccann JL, Wang J, et al., 2020, The ARF tumor
of patients with autism. Ann Neurol, 57(1): 67–81.
suppressor targets PPM1G/PP2Cgamma to counteract
https://doi.org/10.1002/ana.20315 NF-kappaB transcription tuning cell survival and the
inflammatory response. Proc Natl Acad Sci U S A, 117(51):
19. Paolicelli RC, Bolasco G, Pagani F, et al., 2011, Synaptic
pruning by microglia is necessary for normal brain 32594–32605.
development. Science, 333(6048): 1456–1458. https://doi.org/10.1073/pnas.2004470117
https://doi.org/10.1126/science.1202529 31. Diamant G, Dikstein R, 2013, Transcriptional control by
NF-kappaB: elongation in focus. Biochim Biophys Acta,
20. Donzis EJ, Tronson NC, 2014, Modulation of learning and
memory by cytokines: Signaling mechanisms and long term 1829(9): 937–945.
consequences. Neurobiol Learn Mem, 115: 68–77. https://doi.org/10.1016/j.bbagrm.2013.04.007
https://doi.org/10.1016/j.nlm.2014.08.008 32. Karin M, Delhase M, 2000, The I kappa B kinase (IKK) and
NF-kappa B: Key elements of proinflammatory signalling.
21. Donovan AP, Basson MA, 2017, The neuroanatomy of
autism- a developmental perspective. J Anat, 230(1): 4–15. Semin Immunol, 12(1): 85–98.
https://doi.org/10.1006/smim.2000.0210
https://doi.org/10.1111/joa.12542
33. Roberti A, Chaffey LE, Greaves DR, 2022, NF-kappaB
22. Varghese M, Keshav N, Jacot-Descombes S, et al., 2017,
Autism spectrum disorder: Neuropathology and animal signaling and inflammation-drug repurposing to treat
models. Acta Neuropathol, 134(4): 537–566. inflammatory disorders? Biology (Basel), 11(3): 372.
https://doi.org/10.3390/biology11030372
https://doi.org/10.1007/s00401-017-1736-4
34. Okun E, Griffioen KJ, Lathia JD, et al., 2009, Toll-like receptors
23. Li Q, Zhang L, Shan H, et al., 2022, The immuno-behavioural
covariation associated with the treatment response to in neurodegeneration. Brain Res Rev, 59(2): 278–292.
bumetanide in young children with autism spectrum https://doi.org/10.1016/j.brainresrev.2008.09.001

Volume 1 Issue 3 (2022) 10 https://doi.org/10.36922/an.v1i3.167