Page 47 - AN-3-4

Advanced Neurology Anticoagulants as neuroprotective therapeutics

82. Hur JY, Frost GF, Wu X, et al. The innate immunity protein transmission of amyloid-β pathology and cerebral amyloid
IFITM3 modulates γ-secretase in Alzheimer’s disease. angiopathy. Nature. 2015;525(7568):247-250.
Nature. 2020;586(7831):735-740.
doi: 10.1038/nature15369
doi: 10.1038/s41586-020-2681-2
93. Banerjee G, Farmer SF, Hyare H, et al. Iatrogenic Alzheimer’s
83. McAlpine CS, Park J, Griciuc A, et al. Astrocytic interleukin-3 disease in recipients of cadaveric pituitary-derived growth
programs microglia and limits Alzheimer’s disease. Nature. hormone. Nat Med. 2024;30(2):394-402.
2021;595(7869):701-706.
doi: 10.1038/s41591-023-02729-2
doi: 10.1038/s41586-021-03734-6
94. Wang J, Gu BJ, Masters, CL, Wang YJ. A systemic view of
84. Vellecco V, Saviano, A, Raucci F, et al. Interleukin-17 Alzheimer’s disease-insights from amyloid-β metabolism
(IL-17) triggers systemic inflammation, peripheral beyond the brain. Nat Rev. 2017;13:612-623.
vascular dysfunction, and related prothrombotic state in doi: 10.1038/nrneurol.2017.111
a mouse model of Alzheimer’s disease. Pharmacol Res.
2023;187:106595. 95. Cruz Hernandez JC, Bracko O, Kersbergen CJ, et al.
Neutrophil adhesion in brain capillaries reduces cortical
doi: 10.1016/j.phrs.2022.106595
blood flow and impairs memory function in Alzheimer’s
85. Wiesmann M, Zerbi V, Jansen D, et al. Hypertension, disease mouse models. Nat Neurosci. 2019;22(3):413-420.
cerebrovascular impairment, and cognitive decline in aged doi: 10.1038/s41593-018-0329-4
AβPP/PS1 mice. Theranostics. 2017;7(5):12771289.
96. Badimon, A, Torrente D, Norris EH. Vascular dysfunction
doi: 10.7150/thno.18509
in Alzheimer’s disease: Alterations in the plasma contact and
86. Profaci CP, Munij RN, Pulido RS, Daneman R. The blood- fibrinolytic systems. Int J Mol Sci. 2023;24(8):7046.
brain barrier in health and disease: Important unanswered doi: 10.3390/ijms24087046
questions. J Exp Med. 2020;217(4):e20190062.
97. Cortes-Canteli M, Mattei L, Richards AT, Norris EH,
doi: 10.1084/jem.20190062
Strickland S. Fibrin deposited in the Alzheimer’s disease
87. Quintana DD, Anantula Y, Garcia JA, et al. Microvascular brain promotes neuronal degeneration. Neurobiol Aging.
degeneration occurs before plaque onset and progresses with 2015;36(2):608-617.
age in 3xTg AD mice. Neurobiol Aging. 2021;105:115-128.
doi: 10.1016/j.neurobiolaging.2014.10.030
doi: 10.1016/j.neurobiolaging.2021.04.019
98. Ahn HJ, Zamolodchikov D, Cortes-Canteli M,
88. Iturria-Medina Y, Sotero RC, Toussaint PJ, Mateos-Perez JM, Norris EH, Glickman JF, Strickland S. Alzheimer’s disease
Evans AC, The Alzheimer’s Disease Neuroimaging peptide beta-amyloid interacts with fibrinogen and
Initiative. Early role of vascular dysregulation on late-onset induces its oligomerization. Proc Natl Acad Sci U S A.
Alzheimer’s disease based on multifactorial data-driven 2010;107(50):21812-21817.
analysis. Nat Commun. 2016;7:11934.
doi: 10.1073/pnas.1010373107
doi: 10.1038/ncomms11934
99. Bian Z, Yamashita T, Shi X, et al. Accelerated accumulation
89. Nortley, R, Korte N, Izquierdo P, et al. Amyloid β oligomers of fibrinogen peptide chains with Aβ deposition in
constrict human capillaries in Alzheimer’s disease via Alzheimer’s disease (AD) mice and human brains. Brain
signaling to pericytes. Science. 2019;365(6450):eaav9518. Res. 2021;1767:147569.
doi: 10.1126/science.aav9518 doi: 10.1016/j.brainres.2021.147569

90. Cortes-Canteli M, Kruyer A, Fernandez-Nueda I, et al. 100. Singh PK, Chen ZL, Ghosh D, Strickland S, Norris EH.
Long-term dabigatran treatment delays Alzheimer’s disease Increased plasma bradykinin level is associated with
pathogenesis in the TgCRND8 mouse model. J Am Coll cognitive impairment in Alzheimer’s patients. Neurobiol Dis.
Cardiol. 2019;74(15):1910-1923. 2020;139:104833.
doi: 10.1016/j.jacc.2019.07.081 doi: 10.1016/j.nbd.2020.104833
91. DeSimone CV, Graff-Radford J, El-Harasis MA, 101. Bian Z, Feng T, Yu X, et al. Protective effect of rivaroxaban
Rabinstein AA, Asirvatham SJ, Holmes DR Jr. Cerebral against amyloid pathology and neuroinflammation through
amyloid angiopathy: Diagnosis, clinical implications, inhibiting PAR-1 and PAR-2 in Alzheimer’s disease mice.
and management strategies in atrial fibrillation. J Am Coll J Alzheimers Dis. 2022;86(1):111-123.
Cardiol. 2017;70(9):1173-1182.
doi: 10.3233/JAD-215318
doi: 10.1016/j.jacc.2017.07.724
102. Bergamaschini L, Rossi E, Storini C, et al. Peripheral treatment
92. Jaunmuktane Z, Mead S, Ellis M, et al. Evidence for human with enoxaparin, a low molecular weight heparin, reduces

Volume 3 Issue 4 (2024) 29 doi: 10.36922/an.3799