Page 43 - AN-4-1

Advanced Neurology Ferroptosis in neonatal HIBI

activation contributes to ferroptosis-mediated tissue 53. Yang WS, Stockwell BR. Ferroptosis: Death by lipid
injury in intestinal ischemia/reperfusion. Cell Death Differ. peroxidation. Trends Cell Biol. 2016;26(3):165-176.
2019;26(11):2284-2299. doi: 10.1016/j.tcb.2015.10.014
doi: 10.1038/s41418-019-0299-4 54. GPX4 Glutathione Peroxidase 4 [Homo Sapiens (human)].
43. Li C, Wu Z, Xue H, et al. Ferroptosis contributes to National Center for Biotechnology Information.
hypoxic-ischemic brain injury in neonatal rats: Role of the Available from: https://www.ncbi.nlm.nih.gov/
SIRT1/Nrf2/GPx4 signaling pathway. CNS Neurosci Ther. gene/2879#:~:text=Glutathione%20peroxidase%20is%20
2022;28(12):2268-2280. a%20moonlighting [Last accessed on 2024 Oct 10].
doi: 10.1111/cns.13973 55. Zhang Y, Swanda RV, Nie L, et al. mTORC1 couples cyst(e)
ine availability with GPX4 protein synthesis and ferroptosis
44. Wang ZW, Yang LJ, Ding YX, Chang YZ, Cui H. Insights into regulation. Nat Commun. 2021;12(1):1589.
the role of iron in immature rat model of hypoxic-ischemic
brain injury. Exp Ther Med. 2016;12(3):1723-1731. doi: 10.1038/s41467-021-21841-w
doi: 10.3892/etm.2016.3550 56. Song X, Long D. Nrf2 and ferroptosis: A new research
direction for neurodegenerative diseases. Front Neurosci.
45. Yang WS, SriRamaratnam R, Welsch ME, et al. Regulation 2020;14:267.
of ferroptotic cancer cell death by GPX4. Cell. 2014;156(1-
2):317-331. doi: 10.3389/fnins.2020.00267
doi: 10.1016/j.cell.2013.12.010 57. Zhao T, Yu Z, Zhou L, et al. Regulating Nrf2-GPx4 axis by
bicyclol can prevent ferroptosis in carbon tetrachloride-
46. Yang Y, Tang H, Zheng J, Yang K. The PER1/HIF-1alpha induced acute liver injury in mice. Cell Death Discov.
negative feedback loop promotes ferroptosis and inhibits 2022;8(1):380.
tumor progression in oral squamous cell carcinoma. Transl
Oncol. 2022;18:101360. doi: 10.1038/s41420-022-01173-4
58. Hsieh CH, Lin YJ, Chen WL, et al. HIF-1alpha triggers long-
doi: 10.1016/j.tranon.2022.101360
lasting glutamate excitotoxicity via system x(c)(-) in cerebral
47. Zhang M, Lin W, Tao X, et al. Ginsenoside Rb1 inhibits ischaemia-reperfusion. J Pathol. 2017;241(3):337-349.
ferroptosis to ameliorate hypoxic-ischemic brain damage in
neonatal rats. Int Immunopharmacol. 2023;121:110503. doi: 10.1002/path.4838
59. Yuan S, Wei C, Liu G, et al. Sorafenib attenuates liver fibrosis
doi: 10.1016/j.intimp.2023.110503
by triggering hepatic stellate cell ferroptosis via HIF-1alpha/
48. Fotiadis D, Kanai Y, Palacín M. The SLC3 and SLC7 families SLC7A11 pathway. Cell Prolif. 2022;55(1):e13158.
of amino acid transporters. Mol Aspects Med. 2013;34(2- doi: 10.1111/cpr.13158
3):139-158.
60. Stoyanovsky DA, Tyurina YY, Shrivastava I, et al. Iron
doi: 10.1016/j.mam.2012.10.007
catalysis of lipid peroxidation in ferroptosis: Regulated
49. Sato H, Tamba M, Ishii T, Bannai S. Cloning and expression enzymatic or random free radical reaction? Free Radic Biol
of a plasma membrane cystine/glutamate exchange Med. 2019;133:153-161.
transporter composed of two distinct proteins. J Biol Chem. doi: 10.1016/j.freeradbiomed.2018.09.008
1999;274(17):11455-11458.
61. Sun S, Shen J, Jiang J, Wang F, Min J. Targeting ferroptosis
doi: 10.1074/jbc.274.17.11455 opens new avenues for the development of novel
50. Bridges RJ, Natale NR, Patel SA. System xc-cystine/glutamate therapeutics. Signal Transduct Target Ther. 2023;8(1):372.
antiporter: An update on molecular pharmacology and roles doi: 10.1038/s41392-023-01606-1
within the CNS. Br J Pharmacol. 2011;165(1):20-34.
62. Doll S, Freitas FP, Shah R, et al. FSP1 is a glutathione-
doi: 10.1111/j.1476-5381.2011.01480.x independent ferroptosis suppressor. Nature.
51. Tan X, Zhang T, Ding X, et al. Iron overload facilitates 2019;575(7784):693-698.
neonatal hypoxic-ischemic brain damage via SLC7A11- doi: 10.1038/s41586-019-1707-0
mediated ferroptosis. J Neurosci Res. 2023;101(7):1107-1124.
63. Hu Q, Wei W, Wu D, et al. Blockade of GCH1/BH4 axis
doi: 10.1002/jnr.25184 activates ferritinophagy to mitigate the resistance of
52. Kuang F, Liu J, Tang D, Kang R. Oxidative damage and colorectal cancer to erastin-induced ferroptosis. Front Cell
antioxidant defense in ferroptosis. Front Cell Dev Biol. Dev Biol. 2022;10:810327.
2020;8:586578. doi: 10.3389/fcell.2022.810327
doi: 10.3389/fcell.2020.586578 64. Dixon SJ, Winter GE, Musavi LS, et al. Human haploid cell

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