Page 44 - AN-4-1

Advanced Neurology Ferroptosis in neonatal HIBI

genetics reveals roles for lipid metabolism genes in nonapoptotic 75. Evans PJ, Evans R, Kovar IZ, Holton AF, Halliwell B.
cell death. ACS Chem Biol. 2015;10(7):1604-1609. Bleomycin-detectable iron in the plasma of premature and
full-term neonates. FEBS Lett. 1992;303(2-3):210-212.
doi: 10.1021/acschembio.5b00245
doi: 10.1016/0014-5793(92)80521-h
65. Doll S, Proneth B, Tyurina YY, et al. ACSL4 dictates
ferroptosis sensitivity by shaping cellular lipid composition. 76. Khan JY, Black SM. Developmental changes in murine brain
Nat Chem Biol. 2017;13(1):91-98. antioxidant enzymes. Pediatr Res. 2003;54(1):77-82.
doi: 10.1038/nchembio.2239 doi: 10.1203/01.PDR.0000065736.69214.20
66. Feng L, Yin X, Hua Q, Ren T, Ke J. Advancements 77. Roskams AJ, Connor JR. Iron, transferrin, and ferritin in
in understanding the role of ferroptosis in hypxia- the rat brain during development and aging. J Neurochem.
associated brain injury: A narrative review. Transl Pediatr. 1994;63(2):709-716.
2024;13(6):24-47. doi: 10.1046/j.1471-4159.1994.63020709.x
doi: 10.21037/tp-24-47 78. Taylor EM, Morgan EH. Developmental changes in
67. Peeples ES, Genaro-Mattos TC. Ferroptosis: A promising transferrin and iron uptake by the brain in the rat. Brain Res
therapeutic target for neonatal hypoxic-ischemic brain Dev Brain Res. 1990;55(1):35-42.
injury. Int J Mol Sci. 2022;23(13):7420. doi: 10.1016/0165-3806(90)90103-6
doi: 10.3390/ijms23137420 79. Lin W, Zhang T, Zheng J, Zhou Y, Lin Z, Fu X. Ferroptosis is
68. Cheah JG, Kim SF, Hester LD, et al. NMDA receptor-nitric involved in hypoxic-ischemic brain damage in neonatal rats.
oxide transmission mediates neuronal iron homeostasis via Neuroscience. 2022;487:131-142.
the GTPase Dexras1. Neuron. 2006;51(4):431-440. doi: 10.1016/j.neuroscience.2022.02.013
doi: 10.1016/j.neuron.2006.07.011 80. Rice JE 3 , Vannucci RC, Brierley JB. The influence of
rd
69. Yu J, Guo Y, Sun M, Li B, Zhang Y, Li C. Iron is a potential immaturity on hypoxic-ischemic brain damage in the rat.
key mediator of glutamate excitotoxicity in spinal cord Ann Neurol. 1981;9(2):131-141.
motor neurons. Brain Res. 2009;1257:102-107. doi: 10.1002/ana.410090206
doi: 10.1016/j.brainres.2008.12.030 81. Huo L, Fu J, Wang S, Wang H, Liu X. Emerging ferroptosis
70. Parker D, Grillner S. Long-lasting substance-P-mediated inhibitors as a novel therapeutic strategy for the treatment
modulation of NMDA-induced rhythmic activity in the of neonatal hypoxic-ischemic encephalopathy. Eur J Med
lamprey locomotor network involves separate RNA- Chem. 2024;271:116453.
and protein-synthesis-dependent stages. Eur J Neurosci. doi: 10.1016/j.ejmech.2024.116453
2008;11(5):1515-1522.
82. Zhang X, Ding M, Zhu P, et al. New insights into
doi: 10.1046/j.1460-9568.1999.00565.x the Nrf-2/HO-1 signaling axis and its application in
71. Ferriero DM, Sheldon RA, Black SM, Chuai J. Selective pediatric respiratory diseases. Oxid Med Cell Longev.
destruction of nitric oxide synthase neurons with quisqualate 2019;2019:3214196.
reduces damage after hypoxia-ischemia in the neonatal rat. doi: 10.1155/2019/3214196
Pediatr Res. 1995;38(6):912-918.
83. Cai Y, Li X, Tan X, Wang P, Zhao X, Zhang H, et al. Vitamin
doi: 10.1203/00006450-199512000-00014 D suppresses ferroptosis and protects against neonatal
72. Pulera MR, Adams LM, Liu H, et al. Apoptosis in a hypoxic-ischemic encephalopathy by activating the Nrf2/
neonatal rat model of cerebral hypoxia-ischemia. Stroke. HO-1 pathway. Transl Pediatr. 2022;11(10):1633-1644.
1998;29(12):2622-2630. doi: 10.21037/tp-22-397
doi: 10.1161/01.str.29.12.2622 84. Tang Z, Cheng S, Sun Y, et al. Early TLR4 inhibition
73. Dorrepaal CA, Berger HM, Benders MJ, van Zoeren- reduces hippocampal injury at puberty in a rat model of
Grobben D, Van de Bor M, Van Bel F. Nonprotein-bound neonatal hypoxic-ischemic brain damage via regulation
iron in postasphyxial reperfusion injury of the newborn. of neuroimmunity and synaptic plasticity. Exp Neurol.
Pediatrics. 1996;98(5):883-889. 2019;321:113039.
74. Ogihara T, Hirano K, Ogihara H, et al. Non-protein- doi: 10.1016/j.expneurol.2019.113039
bound transition metals and hydroxyl radical generation 85. Fang X, Cai Z, Wang H, et al. Loss of cardiac ferritin H
in cerebrospinal fluid of newborn infants with hypoxic facilitates cardiomyopathy via Slc7a11-mediated ferroptosis.
ischemic encephalopathy. Pediatr Res. 2003;53(4):594-599. Circ Res. 2020;127(4):486-501.
doi: 10.1203/01.PDR.0000054685.87405.59 doi: 10.1161/CIRCRESAHA.120.316509

Volume 4 Issue 1 (2025) 38 doi: 10.36922/an.4575