Page 28 - ARNM-2-4

Advances in Radiotherapy &

Nuclear Medicine

REVIEW ARTICLE
Expert consensus on the utilization of three-

dimensional-printed templates for interstitial
brachytherapy with iodine-125 seeds in the

treatment of recurrent head and neck cancer

Qiman Han 1† , Bin Qiu 1† , Yi Chen 1 , Zhe Ji 1 , Yuliang Jiang , Suqing Tian ,
1
1
2
1
3
Kaixian Zhang , Ruoyu Wang 3 , Zhe Wang , and Junjie Wang *
1 Department of Radiation Oncology, Peking University Third Hospital, Beijing, China
2 Department of Oncology, Tengzhou Central People’s Hospital, Zaozhuang, Shandong, China
3 Department of Medical Oncology, Affiliated Zhongshan Hospital of Dalian University, Dalian,
Liaoning, China

Abstract
Head and neck cancer (HNC) encompasses a range of malignancies that originate
from the upper aerodigestive tract. Despite employing a multimodal treatment
approach, the recurrence rate for HNC remains high with limited treatment options.
One effective treatment method for HNC is interstitial brachytherapy with radioactive
† These authors contributed equally
to this work. seeds, which delivers high localized doses of radiation while minimizing damage to
surrounding healthy tissues. The integration of three-dimensional-printed templates
*Corresponding author:
Junjie Wang (3D-PT) with computed tomography (CT)-guided techniques enhances the precision
(junjiewang@pku.edu.cn) and control of radioactive seed implantation. This approach enhances treatment
Citation: Han Q, Qiu B, Chen Y, accuracy and efficacy, making it a valuable option in the management of HNC
et al. Expert consensus on the and other malignancies. Several factors, such as the specific target site, puncture
utilization of three-dimensional- trajectory, and radiation dosage distribution, can influence the efficacy and safety of
printed templates for interstitial
brachytherapy with iodine-125 seed implantation. At present, there is a lack of comprehensive reports detailing the
seeds in the treatment of clinical and technical processes and standards related to 3D-PT-assisted CT-guided
recurrent head and neck cancer. particle implantation therapy for recurrent HNC. This consensus aims to address this
Adv Radiother Nucl Med.
2024;2(4):4212. gap by focusing on the application of 3D-PTs for interstitial brachytherapy using
doi: 10.36922/arnm.4212 iodine-125 seeds in the treatment of recurrent HNC.
Received: July 11, 2024
Accepted: September 25, 2024 Keywords: 3D-printing template; Iodine-125 seeds; Radioactive seed implantation;
Brachytherapy; Recurrent head and neck cancer
Published Online: January 2, 2025
Copyright: © 2024 Author(s).
This is an Open-Access article
distributed under the terms of the
Creative Commons Attribution 1. Introduction
License, permitting distribution,
and reproduction in any medium, Head and neck cancer (HNC) refers to a diverse group of malignancies that originate
1
provided the original work is from the anatomical sites of the upper aerodigestive tract. HNC typically encompasses
properly cited. neck neoplasms, otolaryngology malignancies, and oral-maxillofacial tumors, including
Publisher’s Note: AccScience nasopharyngeal carcinoma, oropharyngeal carcinoma, hypopharyngeal carcinoma, oral
Publishing remains neutral with cancer, paranasal sinus cancer, laryngeal cancer, thyroid cancer, salivary gland cancer,
regard to jurisdictional claims in
published maps and institutional and primary unknown metastatic neck cancer. Notably, squamous cell carcinoma of the
affiliations head and neck accounts for approximately 90% of these cases. Other histological types,
1

Volume 2 Issue 4 (2024) 1 doi: 10.36922/arnm.4212