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Advances in Radiotherapy
& Nuclear Medicine 3D-PT-assisted CT-guided I RSI
125

Table 3. Clinical outcomes of iodine‑125 radioactive seed implantation for head and neck cancer with computed tomography
guidance
Author Year Design Simple Median Local control Median Survival rate Complications
size local rate survival
control
Li et al. 43 2016 Retrospective 34 17.7 m 1-y 65.3%, 2-y 12.5 m 1-y 55.2%, 2-y Five (15%) patients
28.6%, 3-y 9.5% 20.3%, 3-y 10.9% experienced Grade III toxic
events, and nine (26%)
patients experienced Grade II
toxic events.
Ji et al. 22 2018 Retrospective 101 10 m 1-y 40.6%, 3-y 15 1-y 54.3%, 3-y 26 (25.7%) cases of skin
26.6%, 5-y 26.6% 15.5%, 5-y 15.5% or mucosa ulceration, 14
(13.9%) cases of pain, and two
(2%) cases of dry mouth.
Jiang et al. 44 2021 Multicenter 113 15 m 1-y 57.4%, 2-y 20 m 1-y 63.6%, 2-y 18 (15.9%) cases of Grade I/
retrospective 41.8%, 3-y 29.3%, 44.6%, 3-y 29.9%, II, eight (7.0%) cases of Grade
5-y 15.2% 5-y 21.7% III radiation dermatitis, 14
(12.4%) cases of Grade I/
II, and three (2.7%) cases of
Grade III mucosal reactions.
Zhang et al. 45 2024 Retrospective 132 16 m 1-y 47%, 2-y 22% 15 m 1-y 42%, 2-y 27% Grade I skin toxicity occurred
in seven (5.3%) cases, Grade IV
skin toxicity in one (0.8%) case,
Grade I mucosal ulcer in four
(3.0%) cases, and Grade I dry
mouth in four (3.0%) cases.
Abbreviations: m: Months; y: Year.

Table 4. Clinical outcomes of iodine‑125 radioactive seed implantation for head and neck cancer with three‑dimensional printed
template assistance
Author Year Design Sample Median Local Median Survival rate Complications
size local control control rate survival
Huang 2016 Retrospective 25 - - - - No abnormal hemorrhages or anatomical
et al. 14 complications related to inaccurately
placed implants were observed.
Liang 2018 Retrospective 15 - - - - No intraoperative complications and
et al. 40 post-operative complications were
observed in 3 days.
Jiang et al. 24 2018 Retrospective 42 - - - - Three cases had a grade I skin reaction.
Blood toxicity did not occur, nor did
spinal cord injury.
Qiu et al. 25 2021 Retrospective 41 7 m 3-m 63.2% 12 m - The two major complications were
mucosal and skin ulcers. Minor
radiodermatitis (n=2) and skin
pigmentation (n=1) improved without
additional treatment.
Li et al. 46 2023 Retrospective 33 10 m 1-y 47.8%, 8 m 1-y 41.3%, 2-y Pain was found in three (9.1%) patients,
2-y 36.4% 32.2% followed by Grade I to II acute skin
reactions in three (9.1%) patients, Grade
II to III late skin reactions in two (6.1%)
patients, Grade I to II early mucosal
reactions in four (12.1%) patients, and
mandibular osteonecrosis in one (3.0%)
patient.
Note: “-” refers to not reported.
Abbreviations: m: Months, y: Year.

Volume 2 Issue 4 (2024) 9 doi: 10.36922/arnm.4212