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Advances in Radiotherapy
            & Nuclear Medicine                                                 EZH2 inhibition in ARID1A-deficient TNBC



            may provide a new population of resistant patients with   J Cell Physiol. 2015;230(11):2683-2694.
            treatments that could increase immunogenicity, manage      doi: 10.1002/jcp.24991
            tumor growth, improve survival, and enhance quality of life.
                                                               6.   Shen J, Ju Z, Zhao W, et al. ARID1A deficiency promotes
            Acknowledgments                                       mutability and potentiates therapeutic antitumor immunity
                                                                  unleashed by immune checkpoint blockade.  Nat  Med.
            Figures created in BioRender.com by Evelina VanderSpek   2018;24(5):556-562.
            and Lauren Lukas.
                                                                  doi: 10.1038/s41591-018-0012-z
            Funding                                            7.   Wang Y, Chen Z, Wu J, Yan H, Wang Y, He J. The mutation
                                                                  and low expression of  arid1a are predictive of  a poor
            None.
                                                                  prognosis and high immune infiltration in triple-negative
            Conflict of Interest                                  breast cancer. Curr Cancer Drug Targets. 2023;59-68.
                                                                  doi: 10.2174/1568009623666230522115229
            The authors declare they have no competing interests.
                                                               8.   Sun D, Tian L, Zhu Y,  et al. Subunits of ARID1 serve as
            Author contributions                                  novel biomarkers for the sensitivity to immune checkpoint
                                                                  inhibitors and prognosis of advanced non-small cell lung
            Conceptualization: Lauren Lukas                       cancer. Mol Med. 2020;26(1):78.
            Visualization: Lauren Lukas
            Writing – original draft: Lauren Lukas                doi: 10.1186/s10020-020-00208-9
            Writing – review & editing: All authors            9.   Kim YB, Ahn JM, Bae WJ, Sung CO, Lee D. Functional loss
                                                                  of ARID1A is tightly associated with high PD-L1 expression
            Ethics approval and consent to participate            in gastric cancer. Int J Cancer. 2019;145(4):916-926.
            Not applicable.                                       doi: 10.1002/ijc.32140
            Consent for publication                            10.  Sun M, Gu Y, Fang H, et al. Clinical outcome and molecular
                                                                  landscape of patients with ARID1A-loss gastric cancer.
            Not applicable.                                       Cancer Sci. 2024;115(3):905-915.
            Availability of data                                  doi: 10.1111/cas.16057
                                                               11.  Jung US, Min KW, Kim DH, Kwon MJ, Park H, Jang HS.
            Not applicable.                                       Suppression of ARID1A associated with decreased CD8 T
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            Volume 3 Issue 1 (2025)                         40                             doi: 10.36922/arnm.5132
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