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Advances in Radiotherapy
            & Nuclear Medicine                                                 EZH2 inhibition in ARID1A-deficient TNBC



               2013;15(2):149-160.                                radiation therapies. Lab Invest. 2022;102(2):185-193.
               doi: 10.1093/neuonc/nos285                         doi: 10.1038/s41374-021-00700-8
            104. Agrawal R, Chen M, Bukhari Z, Ogunwobi OO, Haseeb MA,   114. Park Y, Chui MH, Suryo Rahmanto Y, et al. Loss of ARID1A
               Martello LA. EZH2 Downregulation augments the effect of   in tumor cells renders selective vulnerability to combined
               irradiation in reducing pancreatic cancer cell proliferation   ionizing radiation and PARP inhibitor therapy. Clin Cancer
               in vitro. Ann Clin Lab Sci. 2020;50(1):45-56.      Res. 2019;25(18):5584-5594.
            105. Cai MY, Tong ZT, Zhu W,  et al. H3K27me3 protein is a      doi: 10.1158/1078-0432.Ccr-18-4222
               promising predictive biomarker of patients’ survival and
               chemoradioresistance in human nasopharyngeal carcinoma.   115. Neagu AN, Bruno P, Johnson KR, Ballestas G, Darie CC.
               Mol Med. 2011;17(11-12):1137-1145.                 Biological basis of breast cancer-related disparities in
                                                                  precision oncology era. Int J Mol Sci. 2024;25(7):4113.
               doi: 10.2119/molmed.2011.00054
                                                                  doi: 10.3390/ijms25074113
            106. Kuser-Abali G, Gong L, Yan J,  et al. An EZH2-mediated
               epigenetic mechanism behind P53-dependent tissue   116. Werner RJ, Kelly AD, Issa JJ. Epigenetics and precision
               sensitivity to DNA damage.  Proc Natl Acad Sci U S A.   oncology. Cancer J. 2017;23(5):262-269.
               2018;115(13):3452-3457.
                                                                  doi: 10.1097/ppo.0000000000000281
               doi: 10.1073/pnas.1719532115
                                                               117. Durán M, Faull I, Lastra E, Laes JF, Rodrigo AB, Sánchez-
            107. Brenneman RJ, Sharifai N, Fischer-Valuck B, et al. Abscopal   Escribano R. ARID1A genomic alterations driving
               effect following proton beam radiotherapy in a patient with   microsatellite instability through somatic MLH1 methylation
               inoperable metastatic retroperitoneal sarcoma. Front Oncol.   with response to immunotherapy in metastatic lung
               2019;9:922.                                        adenocarcinoma: A case report. J Med Case Rep. 2021;15(1):89.
               doi: 10.3389/fonc.2019.00922                       doi: 10.1186/s13256-020-02589-1
            108. Wu C, Jin X, Yang J, et al. Inhibition of EZH2 by chemo- and   118. Goswami S, Chen Y, Anandhan S, et al. ARID1A mutation
               radiotherapy agents and small molecule inhibitors induces   plus CXCL13 expression act as combinatorial biomarkers to
               cell death in castration-resistant prostate cancer. Oncotarget.
               2016;7(3):3440-3452.                               predict responses to immune checkpoint therapy in mUCC.
                                                                  Sci Transl Med. 2020;12(548):eabc4220.
               doi: 10.18632/oncotarget.6497
                                                                  doi: 10.1126/scitranslmed.abc4220
            109. Klaus CR, Keats JA, Smith JJ, et al. Tazemetostat displays
               synergistic antiproliferative activity with backbone therapies   119. Li L, Li M, Jiang Z, Wang X. ARID1A mutations are associated
               in preclinical models of AT/RT and MRT.  Cancer Res.   with increased immune activity in gastrointestinal cancer.
               2017;77(13):1944.                                  Cells. 2019;8(7):678.
               doi: 10.1158/1538-7445.AM2017-1944                 doi: 10.3390/cells8070678
            110. Gounder MM, Zhu G, Roshal L, et al. Immunologic correlates   120. Pignata S, Califano D, Lorusso D,  et al. MITO END-
               of  the abscopal effect  in a  SMARCB1/INI1-negative   3: Efficacy of avelumab immunotherapy according to
               poorly differentiated chordoma after EZH2 inhibition and   molecular profiling in first-line endometrial cancer therapy.
               radiotherapy. Clin Cancer Res. 2019;25(7):2064-2071.  Ann Oncol. 2024;35(7):667-676.
               doi: 10.1158/1078-0432.Ccr-18-3133                 doi: 10.1016/j.annonc.2024.04.007
            111. Johnsrud AJ, Jenkins SV, Jamshidi-Parsian A, et al. Evidence   121. Zhou H, Sun D, Song S, et al. Efficacy of immunotherapy
               for early stage anti-tumor immunity elicited by spatially   in arid1a-mutant solid tumors: A single-center retrospective
               fractionated radiotherapy-immunotherapy combinations.   study. Discov Oncol. 2024;15(1):213.
               Radiat Res. 2020;194(6):688-697.
                                                                  doi: 10.1007/s12672-024-01074-1
               doi: 10.1667/rade-20-00065.1
                                                               122. Nutt SL, Keenan C, Chopin M, Allan RS. EZH2 function in
            112. Lukas L, Zhang H, Cheng K, Epstein A. Immune priming   immune cell development. Biol Chem. 2020;401(8):933-943
               with spatially fractionated radiation therapy.  Curr Oncol
               Rep. 2023;25(12):1483-1496.                        doi: 10.1515/hsz-2019-0436
               doi: 10.1007/s11912-023-01473-7                 123. Kim HJ, Cantor H, Cosmopoulos K. Overcoming immune
                                                                  checkpoint blockade resistance via EZH2 inhibition. Trends
            113.  Qi L, Lindsay H, Kogiso M, et al. Evaluation of an EZH2 inhibitor   Immunol. 2020;41(10):948-963.
               in patient-derived orthotopic xenograft models of pediatric
               brain tumors alone and in combination with chemo-  and      doi: 10.1016/j.it.2020.08.010



            Volume 3 Issue 1 (2025)                         45                             doi: 10.36922/arnm.5132
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