Page 100 - ARNM-3-2

Advances in Radiotherapy &

Nuclear Medicine

SHORT COMMUNICATION
Study on the impact of treatment planning

system target volume delineation on the efficacy
of iodine-125 seed therapy for non-small cell

lung cancer

Ke Xu , Xiaoli Liu , Jinxin Zhao , Zezhou Liu , Guohui Cao , Juan Wang ,
and Hongtao Zhang*

Department of Oncology, Hebei Provincial Radioactive Seeds Brachytherapy Institute Hebei
Provincial Tumor, Radioactive Seeds Implantation Diagnosis and Treatment Center, Hebei General
Hospital, Shijiazhuang, China

Abstract
This study evaluates the impact of target delineation on the dosimetric outcomes
and therapeutic efficacy of iodine-125 seed implantation in the treatment of non-
small cell lung cancer. A retrospective analysis was conducted on 31 patients who
underwent iodine-125 seed implantation at our center. Post-operative dosimetric
parameters, including target volume (Vol), minimum peripheral dose received by
90% of the target Vol (D ), as well as the percentage of target Vol covered by 100%
90
*Corresponding author: (V ), 150% (V ), and 200% (V ) of the prescription dose, were recorded. Patients
Hongtao Zhang 100 150 200
(90030109@hebmu.edu.cn) were divided into two groups based on treatment response: Group A (complete
remission [CR]) and Group B (non-CR group). In addition, the gross target Vol
Citation: Xu K, Liu X, Zhao J,
et al. Study on the impact of (GTV) of both groups was expanded by 5 mm (clinical target volume [CTV] 5mm ) and
treatment planning system target 1 cm (CTV 1mm ), and the corresponding dosimetric parameters were obtained. The
volume delineation on the efficacy independent sample t-tests were used to assess differences between the two groups.
of iodine-125 seed therapy for
non-small cell lung cancer. Adv All patients successfully completed surgery; among them, 15 achieved CR, 12 had
Radiother Nucl Med. partial response, three had stable disease, and one experienced disease progression.
2025;3(2):92-97. Intraoperative complications included pneumothorax (32%), with three cases
doi: 10.36922/arnm.8512
(10%) requiring pleural drainage, and intrapulmonary hemorrhage (42%), including
Received: January 13, 2025 hemoptysis (13%), all of which recovered after hemostatic treatment. No other
Revised: February 14, 2025 adverse reactions occurred. Statistical analysis revealed no significant difference
in dosimetric parameters between the two groups immediately after surgery.
Accepted: March 19, 2025
However, for CTV 5mm , D was significantly lower than its immediate post-operative
90
Published online: June 25, 2025 value (p=0.03, <0.05), whereas the other parameters were not significantly different.
Copyright: © 2025 Author(s). Expanding the GTV by 5 mm to define the CTV improves treatment outcomes and
This is an Open-Access article may enhance local tumor control.
distributed under the terms of the
Creative Commons Attribution
License, permitting distribution, Keywords: Target delineation; Brachytherapy; Treatment efficacy; Dosimetric outcomes
and reproduction in any medium,
provided the original work is
properly cited.
Publisher’s Note: AccScience
Publishing remains neutral with 1. Introduction
regard to jurisdictional claims in
published maps and institutional Lung cancer is a malignant tumor with a high incidence and mortality rate worldwide.
affiliations. Non-small cell lung cancer (NSCLC) comprises approximately 80% of all lung cancer

Volume 3 Issue 2 (2025) 92 doi: 10.36922/arnm.8512