Page 99 - ARNM-3-3
P. 99
Advances in Radiotherapy
& Nuclear Medicine Cripto-1 in cancer diagnosis and therapy
19. Lin XL, Zhao WT, Jia JS, et al. Ectopic expression of stem cells. Adv Drug Deliv Rev. 2015;88:3-15.
Cripto-1 in transgenic mouse embryos causes hemorrhages, doi: 10.1016/j.addr.2015.04.004
fatal cardiac defects and embryonic lethality. Sci
Rep. 2016;6:34501. 30. Park KS, Moon YW, Raffeld M, Lee DH, Wang YS,
Giaccone G. High cripto-1 and low miR-205 expression
doi: 10.1038/srep34501
levels as prognostic markers in early stage non-small cell
20. Klauzinska M, McCurdy D, Rangel MC, et al. Cripto-1 lung cancer. Lung Cancer. 2018;116:38-45.
ablation disrupts alveolar development in the mouse doi: 10.1016/j.lungcan.2017.12.010
mammary gland through a progesterone receptor-mediated
pathway. Am J Pathol. 2015;185(11):2907-2922. 31. Xiaojun B, Yanjun X, Yilun L. MicroRNA-3653-3p inhibited
papillary thyroid carcinoma progression by regulating
doi: 10.1016/j.ajpath.2015.07.023
CRIPTO-1. Cell Mol Biol. 2024;69(14):272-276.
21. Sousa ER, Zoni E, Karkampouna S, et al. A multidisciplinary doi: 10.14715/cmb/2023.69.14.45
review of the roles of cripto in the scientific literature through
a bibliometric analysis of its biological roles. Cancers (Basel). 32. Arnouk H, Yum G, Shah D. Cripto-1 as a key factor in
2020;12(6):1480. tumor progression, epithelial to mesenchymal transition
and cancer stem cells. Int J Mol Sci. 2021;22(17):9280.
doi: 10.3390/cancers12061480
doi: 10.3390/ijms22179280
22. Nagaoka T, Karasawa H, Castro NP, Rangel MC, Salomon DS,
Bianco C. An evolving web of signaling networks regulated 33. Liu R, Li XQ, Gao WM, et al. Monoclonal antibody against
by cripto-1. Growth Factors. 2012;30(1):13-21. cell surface GRP78 as a novel agent in suppressing PI3K/
AKT signaling, tumor growth, and metastasis. Clin Cancer
doi: 10.3109/08977194.2011.641962
Res. 2013;19(24):6802-6811.
23. Morkel M, Huelsken J, Wakamiya M, et al. β-Catenin doi: 10.1158/1078-0432.Ccr-13-1106
regulates Cripto- and Wnt3-dependent gene expression
programs in mouse axis and mesoderm formation. 34. Ni M, Zhang Y, Lee AS. Beyond the endoplasmic reticulum:
Development. 2003;130(25):6283-6294. Atypical GRP78 in cell viability, signalling and therapeutic
targeting. Biochem J. 2011;434:181-188.
doi: 10.1242/dev.00859
doi: 10.1042/Bj20101569
24. Watanabe K, Nagaoka T, Lee JM, et al. Enhancement of
Notch receptor maturation and signaling sensitivity by 35. Kelber JA, Panopoulos AD, Shani G, et al. Blockade of
cripto-1. J Cell Biol. 2009;187(3):343-353. cripto binding to cell surface GRP78 inhibits oncogenic
cripto signaling via MAPK/PI3K and Smad2/3 pathways.
doi: 10.1083/jcb.200905105
Oncogene. 2009;28(24):2324-2336.
25. Bianco C, Cotten C, Lonardo E, et al. Cripto-1 is required doi: 10.1038/onc.2009.97
for hypoxia to induce cardiac differentiation of mouse
embryonic stem cells. Am J Pathol. 2009;175(5):2146-2158. 36. Castaneda M, Den Hollander P, Kuburich NA, Rosen JM,
Mani SA. Mechanisms of cancer metastasis. Semin Cancer
doi: 10.2353/ajpath.2009.090218
Biol. 2022;87:17-31.
26. Hamada S, Watanabe K, Hirota M, et al. β-catenin/TCF/
LEF regulate expression of the short form human Cripto-1. doi: 10.1016/j.semcancer.2022.10.006
Biochem Bioph Res Commun. 2007;355(1):240-244. 37. Dongre A, Weinberg RA. New insights into the mechanisms
of epithelial-mesenchymal transition and implications for
doi: 10.1016/j.bbrc.2007.01.143
cancer. Nat Rev Mol Cell Biol. 2019;20(2):69-84.
27. Mancino M, Strizzi L, Wechselberger C, et al. Regulation doi: 10.1038/s41580-018-0080-4
of human cripto-1 gene expression by TGF-beta1 and
BMP-4 in embryonal and colon cancer cells. J Cell Physiol. 38. Balcioglu O, Heinz RE, Freeman DW, et al. CRIPTO
2008;215(1):192-203. antagonist ALK4-Fc inhibits breast cancer cell plasticity and
adaptation to stress. Breast Cancer Res. 2020;22(1):125.
doi: 10.1002/jcp.21301
doi: 10.1186/s13058-020-01361-z
28. Bianco C, Castro NP, Baraty C, et al. Regulation of human
Cripto-1 expression by nuclear receptors and DNA promoter 39. Lambert AW, Weinberg RA. Linking EMT programmes to
methylation in human embryonal and breast cancer cells. normal and neoplastic epithelial stem cells. Nat Rev Cancer.
J Cell Physiol. 2013;228(6):1174-1188. 2021;21(5):325-338.
doi: 10.1002/jcp.24271 doi: 10.1038/s41568-021-00332-6
29. Ong SG, Lee WH, Kodo K, Wu JC. MicroRNA-mediated 40. Fiorenzano A, Pascale E, D’Aniello C, et al. Cripto is essential
regulation of differentiation and trans-differentiation in to capture mouse epiblast stem cell and human embryonic
Volume 3 Issue 3 (2025) 91 doi: 10.36922/ARNM025130015

