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Brain & Heart                                                        Balloon valvuloplasty for aortic stenosis






















                                                               Figure 17. The role of repeat balloon aortic valvuloplasty (BAV) in two
                                                               different patients. In both patients, peak aortic valve gradients fell after
                                                               the first BAV (1stB), but at follow-up (FU), the gradient rose. On repeat
            Figure 15. Graph illustrating the results of balloon aortic valvuloplasty   BAV (2ndB), the pressure gradients decreased and stayed low at 6-year
            (BAV) based on outcomes. In the favorable outcomes group (Group I),   (6Yr) FU by Doppler (D) assessment. Note: Pre: Before BAV. Reproduced
            the aortic valve peak gradients fell (p  < 0.001) immediately (IMM)   from Rao et al. 65
            after BAV and remained low (p  > 0.1) at follow-up (FU) (left panel).
            In the poor results group (Group  II), the aortic valve peak gradients
            fell (p  < 0.01) immediately after BAV but increased (p  < 0.01) at FU
            (right panel). Mean ± standard error of the mean (SEM) is indicated.
            Reproduced from Rao. 20

















                                                               Figure  18. Diagram displaying the magnitude of aortic insufficiency
                                                               (AI) evaluated in Doppler studies before (Pre), the day following (Post)
                                                               balloon aortic valvuloplasty (BAV), and at long-term follow-up (FU). An
                                                               increase (p = 0.002) in AI from pre-BAV to post-BAV was observed. At
            Figure 16. Chart illustrating the role of the number of risk factors on the   late FU, the AI increased further, with grade 3+ AI identified in seven out
            frequency of restenosis following balloon aortic valvuloplasty. The higher   of 26 patients (p < 0.02). Reproduced from Galal et al. 19
            the number of risk factors, the greater the likelihood of re-obstruction
            (p = 0.01). The actual number of patients and percentages are displayed
            on the cap of each bar. Reproduced from Rao. 11    beneficial in relieving AVS in fetuses, 78-92  full-term 93-97 ,
                                                               and premature 98-104  neonates, as well as in adolescents and
                                                                          105
            quantitated post-BAV AI predicts the late onset of AI   young adults.  These age groups are not discussed further
            (Figure 20). Large B/A ratios were thought to be producing   here, and interested readers may review the data in the
            AI both in animal models  and clinical cases. 76,77  Therefore,   cited references. In the elderly with calcific AVS, BAV was
                                76
            we plotted the relationship between the level of AI at   initially considered a useful technique. 10,106-109  However,
            long-term and B/A ratios (Figure 21) and were unable to   subsequent evaluations revealed that BAV provides only
            demonstrate a positive relationship. 19            temporary relief for calcific AVS in the elderly. 110,111  As a
                                                               result, BAV is no longer recommended for this age group.
            6. Aortic stenosis in other age groups             Instead, the replacement of the aortic valve through
                                                                                    112
            The preceding sections provide  an overview of the   transcatheter methodology  has become the procedure of
            outcomes of BAV in children. BAV has also been proven   choice. 112-114


            Volume 2 Issue 3 (2024)                         6                                doi: 10.36922/bh.2914
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