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Brain & Heart Lipids in ALS: Bad and beneficial

A B

C D E

Figure 2. Interaction of the binding poses: (A) resveratrol and O60218, (B) resveratrol and P23280, (C) resveratrol and Q9H4B7, (D) resveratrol and
Q9Y2D0, and (E) resveratrol and Q16236

A B

Figure 3. Interaction of the binding poses: (A) rotenone and P03905 and (B) rotenone and P33261
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Resveratrol, a polyphenol found in various plants, prolonged the lifespan of ALS mice. Furthermore, in the
exhibits potential neuroprotective activity by affecting SOD1 G93A mouse model of ALS, a resveratrol-enriched diet
processes such as nuclear factor-kappa B (NF-κB) demonstrated protective effects associated with increased
activation and activator protein-1 DNA binding. 29,34 The expression and activation of sirtuin 1 and AMPK in the
administration of resveratrol has displayed protective ventral spinal cord. Delivery of resveratrol to the brain
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effects on rat cortical motor neurons against the toxicity through nanocarriers has been suggested to optimize its
of CSF in ALS patients. In addition, oral intake of pharmacokinetics and effectiveness in preventing and
2
resveratrol at 160 mg/kg/day improved motor abilities and treating neurological disorders. However, recent research
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Volume 2 Issue 3 (2024) 9 doi: 10.36922/bh.2976