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Brain & Heart                                                                Advances in stroke treatment



            5.   Nogueira RG, Jadhav AP, Haussen DC, et al. Thrombectomy   acute middle cerebral artery stroke. PROACT Investigators.
               6 to 24 hours after stroke with a mismatch between deficit   Prolyse in acute cerebral thromboembolism.  Stroke.
               and infarct. N Engl J Med. 2018;378(1):11-21.      1998;29(1):4-11.
               doi: 10.1056/NEJMoa1706442                         doi: 10.1161/01.str.29.1.4
            6.   Haley EC Jr., Thompson JL, Grotta JC, et al., Phase IIB/III   15.  Furlan A, Higashida R, Wechsler L,  et al. Intra-arterial
               trial of tenecteplase in acute ischemic stroke: Results of a   prourokinase for acute ischemic stroke. The PROACT II
               prematurely terminated randomized clinical trial.  Stroke.   study: A randomized controlled trial. Prolyse in acute cerebral
               2010;41(4):707-711.                                thromboembolism. JAMA. 1999;282(21):2003-2011.
               doi: 10.1161/STROKEAHA.109.572040                  doi: 10.1001/jama.282.21.2003
            7.   Parsons M, Spratt N, Bivard A,  et al. A  randomized trial   16.  Li S, Gu HQ, Feng B, et al. Safety and efficacy of intravenous
               of tenecteplase versus alteplase for acute ischemic stroke.   recombinant human prourokinase for acute ischaemic stroke
               N Engl J Med. 2012;366(12):1099-1107.              within 4·5 h after stroke onset (PROST-2): A phase 3, open-
               doi: 10.1056/NEJMoa1109842                         label, non-inferiority, randomised controlled trial.  Lancet
                                                                  Neurol. 2025;24(1):33-41.
            8.   Huang X, Cheripelli BK, Lloyd SM, et al. Alteplase versus
               tenecteplase for thrombolysis after ischaemic stroke      doi: 10.1016/S1474-4422(24)00436-8
               (ATTEST): A  phase 2, randomised, open-label, blinded   17.  Xiong Y, Hao M, Pan Y,  et al. Rationale and design of
               endpoint study. Lancet Neurol. 2015;14(4):368-376.  ProUrokinase in Mild IsChemic strokE (PUMICE):
                                                                  A  multicentre, prospective,  randomised, open-label,
               doi: 10.1016/S1474-4422(15)70017-7
                                                                  blinded-endpoint controlled trial.  Stroke Vasc Neurol.
            9.   Campbell BC, Mitchell PJ, Churilov L, et al. Tenecteplase   2024;9(6):715-722.
               versus alteplase before endovascular thrombectomy
               (EXTEND-IA TNK): A multicenter, randomized, controlled      doi: 10.1136/svn-2023-002673
               study. Int J Stroke. 2018;13(3):328-334.        18.  Berkhemer OA, Fransen PS, Beumer D, et al. A randomized
               doi: 10.1177/1747493017733935                      trial of intraarterial treatment for acute ischemic  stroke.
                                                                  N Engl J Med. 2015;372(1):11-20.
            10.  Xiong Y, Campbell BCV, Fisher M, et al. Rationale and design
               of tenecteplase reperfusion therapy in acute ischaemic      doi: 10.1056/NEJMoa1411587
               cerebrovascular Events III (TRACE III): A  randomised,   19.  Liu X, Dai Q, Ye R,  et al. Endovascular treatment versus
               phase  III,  open-label,  controlled  trial.  Stroke Vasc Neurol.   standard medical treatment for vertebrobasilar artery
               2024;9(1):82-89.                                   occlusion (BEST): An open-label, randomised controlled
               doi: 10.1136/svn-2023-002310                       trial. Lancet Neurol. 2020;19(2):115-122.
            11.  Bivard A, Zhao H, Churilov L,  et al. Comparison of      doi: 10.1016/S1474-4422(19)30395-3
               tenecteplase with alteplase for the early treatment of   20.  Drumm B, Banerjee S, Qureshi MM, et al. Current opinions
               ischaemic  stroke  in  the  melbourne  mobile  stroke  unit   on optimal management of basilar artery occlusion: After
               (TASTE-A): A phase 2, randomised, open-label trial. Lancet   the BEST of BASICS survey. Stroke Vasc Intervent Neurol.
               Neurol. 2022;21(6):520-527.                        2022;2:e000538.
               doi: 10.1016/S1474-4422(22)00171-5                 doi: 10.1161/SVIN.122.000538
            12.  Menon BK, Buck BH, Singh N, et al. Intravenous tenecteplase   21.  Edwards C, Drumm B, Siegler JE,  et al. Basilar artery
               compared with alteplase for acute ischaemic stroke in   occlusion  management:  Specialist  perspectives  from  an
               Canada (AcT): A  pragmatic, multicentre, open-label,   international survey. J Neuroimaging. 2023;33:422-433.
               registry-linked, randomised, controlled, non-inferiority
               trial. Lancet. 2022;400(10347):161-169.            doi: 10.1111/jon.13084
                                                               22.  Tao C, Nogueira RG, Zhu Y,  et al. Trial of endovascular
               doi: 10.1016/S0140-6736(22)01054-6
                                                                  treatment of acute basilar-artery occlusion. N Engl J Med.
            13.  Logallo N, Novotny V, Assmus J, et al. Tenecteplase versus   2022;387(15):1361-1372.
               alteplase for management of acute ischaemic stroke (NOR-
               TEST): A phase 3, randomised, open-label, blinded endpoint      doi: 10.1056/NEJMoa2206317
               trial. Lancet Neurol. 2017;16(10):781-788.      23.  Jovin TG, Li C, Wu L, et al. Trial of thrombectomy 6 to 24
                                                                  hours after stroke due to basilar-artery occlusion. N Engl J
               doi: 10.1016/S1474-4422(17)30253-3
                                                                  Med. 2022;387(15):1373-1384.
            14.  Del Zoppo GJ, Higashida RT, Furlan AJ, Pessin MS,
               Rowley HA, Gent M. PROACT: A phase II randomized trial      doi: 10.1056/NEJMoa2207576
               of recombinant pro-urokinase by direct arterial delivery in   24.  Yoshimura S, Sakai N, Yamagami H,  et al. Endovascular


            Volume 3 Issue 3 (2025)                         10                               doi: 10.36922/bh.6683
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