Page 67 - BH-3-3

Brain & Heart

ORIGINAL RESEARCH ARTICLE
Dementia as a risk factor for coronary artery

disease

1
1
Ram B. Singh * , M. A. Niaz , Ajay Agarwal , Aminad Magomedova 3 ,
2
M. A. Manal Smail , Saibal Chakravorty , Yana Danailova , Ghizal Fatima 7 ,
6
4
5
and Miroslav Dobrev 3
1 Department of Medicine, Halberg Hospital and Research Institute, Moradabad, Uttar Pradesh, India
2 Department of Medicine, Fortis Hospital, Noida, Uttar Pradesh, India
3 Department of Population, Lomosonov Moscow State University, Moscow, Russia
4 Department Pharmacy, School of Medicine & Health Sciences, United Arab University, Ajman,
United Arab Emirates
5 Department of Medicine, Metro Multispeciality Hospital, Noida, Uttar Pradesh, India
6 Yana Nutrition Clinic, Sofia, Sofia City, Bulgaria
7 Chronobiology Laboratory, Era Medical College, Era University, Lucknow, Uttar Pradesh, India

Abstract

Western diet and lifestyle are known to predispose to low-grade chronic systemic
inflammation, leading to dementia and coronary artery disease (CAD). It is hypothesized
that dementia may also predispose individuals to CAD, just as it is well-established that
CAD can predispose individuals to dementia. This study investigates the association
between dementia and the risk of developing CAD. All participants (n = 2,002) were
over 25 years old (986 females and 1,016 males), and all were residing in urban areas.
*Corresponding author: Validated instruments, including a modified memory impairment scale, were used
Ram B. Singh
(rbs@tsimtsoum.net) to assess dementia. The association between memory dysfunction and CAD was
evaluated through regression analysis. Definite memory dysfunction was found in
Citation: Singh RB, Niaz MA,
Agarwal A, et al. Dementia as a risk 4.54% of participants, with a higher prevalence in men than in women, and was more
factor for coronary artery disease. common than possible memory dysfunction. Regression analysis, after adjusting for
Brain & Heart. 2025;3(3):8426. age and body mass index, revealed that dementia scores were significantly associated
doi: 10.36922/bh.8426
with CAD risk (p<0.001) in both men (odds ratio [OR]: 0.90, 95% confidence interval
Received: January 6, 2025 [CI]: 0.82 – 0.98) and women (OR: 0.88, CI: 0.81 – 0.96). Similarly, diabetes mellitus scores
Revised: March 28, 2025 were strongly associated with CAD risk (p<0.001) in men (OR: 0.76, CI: 0.68 – 0.87)
and women (OR: 0.77, CI: 0.77 – 0.87). Sedentary behavior and tobacco use were also
Accepted: April 10, 2025
positively associated with CAD in both genders (p<0.05), whereas alcoholism showed
Published online: June 10, 2025 a modest positive association with CAD risk in men but not in women. These findings
Copyright: © 2025 Author(s). suggest a potential association between dementia and CAD risk across genders.
This is an Open-Access article However, larger cohort studies are needed to confirm these results.
distributed under the terms of the
Creative Commons Attribution
License, permitting distribution, Keywords: Memory dysfunction; Memory impairment; Neuronal damage; Brain; Heart
and reproduction in any medium,
provided the original work is
properly cited.
Publisher’s Note: AccScience
Publishing remains neutral with 1. Introduction
regard to jurisdictional claims in
published maps and institutional There is growing evidence that behavioral risk factors, such as unhealthy diet, sedentary
affiliations. behavior, tobacco use, alcoholism, mental health disorders, and sleep disturbances,

Volume 3 Issue 3 (2025) 1 doi: 10.36922/bh.8426