Page 118 - EJMO-9-1

Eurasian Journal of Medicine and
Oncology
HEART and SYNTAX scores

2.2. Data collection and variables (5.0%), history of myocardial infarction (4.2%), family

We collected data on medical history, ECG findings, risk history of CAD (1.7%), and peripheral arterial disease
factors, troponin levels, and additional laboratory values. (0.8%), were associated with lower rates. The biochemical
The HEART score, which includes five major criteria, was characteristics of the study population according to the
calculated for each patient, with a possible score of 0 – 10. SYNTAX score are shown in Table 2. The risk according
The SYNTAX score was determined through coronary to the GRACE score of the group with moderate-to-high
angiography, quantifying the extent and complexity of SYNTAX scores and the group with low SYNTAX score are
coronary lesions. shown in Table 3.

2.3. Statistical analysis 3.2. Correlation between the HEART and SYNTAX
scores
Data were analyzed using SPSS version 26. Logistic
regression and receiver operating characteristic (ROC) A strong correlation was found between the HEART
analysis were applied to assess the predictive value of the and SYNTAX scores in patients with NSTE-ACS, with a
HEART score for the SYNTAX score. The area under the correlation coefficient of ρ = 0.819 and high significance
ROC curve (AUC) was calculated, with P < 0.05 considered (P < 0.001); this indicates that the HEART score may
significant. accurately reflect the severity of coronary lesions as
measured by the SYNTAX score (Figure 1).
2.4. Ethics approval
3.3. Effectiveness of the HEART score in predicting
This research has been approved by the Ethics Council in coronary lesion severity
Biomedical Research of Pham Ngoc Thach University of
Medicine, Decision No. 958/TĐHYKPNT-HDDD. The HEART score shows high accuracy in predicting
severe coronary lesions (SYNTAX score ≥23), with an
3. Results AUC of 0.912. The optimal cutoff point was 5, with 90.6%
sensitivity and 83.9% specificity, which indicates a high
3.1. Patient characteristics predictive ability for coronary lesion severity (Figure 2).
The study enrolled 120 patients, with a mean age of
63.9 ± 9.6 years, of which 80 (66.7%) were men and 3.4. Independent predictive factors for severe
40 (33.3%) were women. The prevalence of common coronary lesions
cardiovascular risk factors in the study population was Multivariate logistic regression analysis shows that the two
notable, with 97 (80.8%) patients having a history of independent predictive factors for severe coronary lesions
hypertension, 88 (73.3%) diagnosed with hyperlipidemia, (moderate-to-high SYNTAX score) are men (OR = 4.412)
31 (25.8%) diagnosed with diabetes, and 20 (16.7%) and a HEART score of ≥5 (OR = 63.002). Although factors
reported as smokers. Other risk factors, such as stroke such as urea, creatinine, and the GRACE score show

Table 2. Biochemical characteristics of the study population according to the SYNTAX score

Variables Moderate‑to‑high SYNTAX score Low SYNTAX score P
Glucose (mmol/L)*** 5.9 (5.1 – 9.3) 6.1 (5.0 – 7.6) 0.641*
Urea (mmol/L)*** 5.5 (4.0 – 8.4) 5.4 (4.5 – 6.6) 0.468*
Creatinine (µmol/L)*** 89.0 (77.0 – 115.0) 86.0 (76.0 – 97.0) 0.315*
eGFR (ml/ph/1.73 m )**** 67.5±21.6 69.3±12.6 0.574**
2
Total cholesterol (mmol/l)*** 4.4 (3.5 – 5.8) 4.6 (3.9 – 5.3) 0.833*
HDL-C (mmol/L)*** 1.0 (0.8 – 1.2) 1.0 (0.9 – 1.2) 0.075*
Triglyceride (mmol/L)*** 1.7 (1.2 – 2.6) 1.9 (1.4 – 2.5) 0.444*
LDL-C (mmol/L)*** 2.4 (1.9 – 3.5) 2.7 (1.9 – 3.2) 0.748*
Troponin I (pg/mL)*** 587.4 (13.0 – 2,859.7) 23.6 (1.7 – 793.7) 0.002*
Notes: *Mann–Whitney test. **Two-sample independent t-test. ***Non-normally distributed variables are presented as median (interquartile range).
****Normally distributed variables are presented as mean±standard deviation. There were similarities in the test results of glucose, urea, creatinine,
eGFR, total cholesterol, HDL-C, triglyceride, and LDL-C between the group with moderate-to-high SYNTAX scores and the group with low SYNTAX
scores. The troponin I concentration in the group with moderate-to-high SYNTAX scores was higher than that in the group with low SYNTAX scores,
and the difference was significant (Mann–Whitney test, P=0.002).
Abbreviations: eGFR: Estimated glomerular filtration rate; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol.

Volume 9 Issue 1 (2025) 110 doi: 10.36922/ejmo.5731