Page 192 - EJMO-9-1

Eurasian Journal of Medicine and
Oncology
Research on hypoxia and ECM in cancer

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Figure 7. Analysis of most commonly cited references. (A) Cluster analysis of co-cited references. (B) Timeline graph of cluster analysis.

The study involved 39 countries/regions. Developed Among the top 10 institutions by publication volume,
nations, such as the USA and the United Kingdom, entered seven are from China and three from the USA. However,
the research field of hypoxia and ECM in cancer earlier, while the top three institutions by citation frequency are all in
emerging countries, such as China and Russia, joined the field the USA, with Johns Hopkins University leading by a
more recently. Despite China’s lead in publication volume, significant margin. Research in this field was initially
it has a lower average citation per paper and intermediary driven by the USA and other developed countries, but in
centrality, probably due to its later entry. The USA, ranking recent years, developing countries have joined through
second in publication volume, is outstanding in both citation international collaboration. Although China now surpasses
frequency and intermediary centrality. Research in this field the USA in publication volume, its research depth and level
is predominantly concentrated in the Northern Hemisphere, of international cooperation remain significantly lower.
with strong connections among North America, Europe, Visualization of author contributions highlights Semenza
and East Asia. Notably, collaborations between North G.L., Wirtz D., and Gilkes D.M. as key contributors to this
America and Europe demonstrate evolving dynamics in field. In addition, Bhujwalla Z.M., Wang Y., and Wirtz D.
global research partnerships. have made substantial contributions. Krishnamachary B.

Volume 9 Issue 1 (2025) 184 doi: 10.36922/ejmo.7116