Page 191 - EJMO-9-1

Eurasian Journal of Medicine and
Oncology
Research on hypoxia and ECM in cancer

Table 6. Top 10 cited literature
Rank Authors Title Year LC GC LC/GC ratio (%) DOI
1 Gilkes D.M. Hypoxia and the extracellular matrix: drivers of 2014 44 1035 4.25 10.1038/nrc3726
tumor metastasis
2 Gilkes D.M. Hypoxia-inducible factor 1 (HIF-1) promotes 2013 27 369 7.32 10.1074/jbc.M112.442939
extracellular matrix remodeling under hypoxic
conditions by inducing P4HA1, P4HA2, and
PLOD2 expression in fibroblasts
3 Gilkes D.M. Procollagen lysyl hydroxylase 2 is essential for 2013 16 191 8.38 10.1158/1541-7786.MCR-12-0629
hypoxia-induced breast cancer metastasis
4 Cox T.R. LOX-mediated collagen crosslinking is 2013 12 406 2.96 10.1158/0008-5472.CAN-12-2233
responsible for fibrosis-enhanced metastasis
5 Petrova V. The hypoxic tumor microenvironment 2018 12 661 1.82 10.1038/s41389-017-0011-9
6 Gong H. Hyaluronidase to enhance nanoparticle-based 2016 11 278 3.96 10.1021/acs.nanolett. 6b00068
photodynamic tumor therapy
7 Ju J.L.A. Hypoxia selectively enhances integrin α5β1 2017 11 87 12.64 10.1158/1541-7786.MCR-16-0338
receptor expression in breast cancer to promote
metastasis
8 Najafi M. Extracellular matrix (ECM) stiffness and 2019 9 380 2.37 10.1002/jcb. 27681
degradation as cancer drivers
9 Saatcl O. Targeting lysyl oxidase (LOX) overcomes 2020 8 180 4.44 10.1038/s41467-020-16199-4
chemotherapy resistance in triple-negative breast
cancer
10 Ereer J.T. Three-dimensional context regulation of 2009 7 242 2.89 10.1007/s10585-008-9209-8
metastasis
Abbreviations: LC: Local citations; GC: Global citations.

Table 7. Clusters of co‑cited references

Cluster Label (LLR) Size Silhouette Average year
0 Cancer-associated fibroblast 66 0.939 2020
1 Tumor angiogenesis 61 0.937 2011
2 TNBC 60 0.742 2019
3 HIF 49 0.962 2014
4 Therapy resistance 40 0.957 2019
5 Glycolysis 32 0.984 2016
6 Tumor microenvironment 27 0.951 2018
7 Breast cancer 24 1 2013
8 Lysyl oxidase 19 0.971 2016
9 Photodynamic immunotherapy 14 1 2016
Note: Average year represents the mean publication year of all references within this cluster.
Abbreviations: LLR: Log-likelihood ratio; TNBC: Triple-negative breast cancer; HIF: Hypoxia-inducible factor.

developmental trends, and potential collaborative networks in 2022, with 52 papers published. The period spanning
of research on hypoxia and ECM in cancer. Among the 351 2007 – 2011 displayed a relatively consistent growth of
papers that met the inclusion criteria, a diverse cohort of publications, while 2011 – 2019 featured slight fluctuations.
2199 authors from 39 countries/regions contributed and The subsequent phase (2019 – 2022) witnessed a notable
published their findings across 201 journals. The literature increase in research productivity. Notably, 2019 marked
concerning this field exhibited a steady upward trajectory the awarding of the Nobel Prize in Physiology or Medicine
from 2007 to 2024, characterized by an annual growth rate for research on HIF-1, and HIF became a research hotspot
of 13.54%. Notably, the peak of publications was observed in the 3 years following 2019.

Volume 9 Issue 1 (2025) 183 doi: 10.36922/ejmo.7116