Page 218 - EJMO-9-1

Eurasian Journal of Medicine and
Oncology Anticoagulant therapy on parathyroid

During thyroid surgery, the main causes of parathyroid This study proposed the use of MaiLuoShuTong pills
dysfunction include inadvertent resection, thermal combined with Daheparin anticoagulant therapy to
damage, contusion, devascularization, or vascular improve hypoparathyroidism. The primary functions of
spasm. 19-21 Larger tumors generally increase surgical these medications include anticoagulation, promoting
complexity, raising the risk of parathyroid injury, circulation, dilating peripheral blood vessels, improving
and consequently, the incidence of post-operative blood supply to the parathyroid glands, and facilitating
hypoparathyroidism. Other surgery-related factors the recovery of parathyroid function. Dalteparin, a low-
include the extent of surgical resection, central lymph molecular-weight heparin, functions by inhibiting clotting
node dissection, and repeat operations. Parathyroid auto- factors in the blood coagulation process, particularly
transplantation and the number of parathyroid glands suppressing thrombin generation, which reduces the
preserved in situ (including monitoring for color changes formation of blood clots. It is commonly used for the
indicative of viability) also significantly affect parathyroid prevention and treatment of thrombotic conditions, such as
function. Accidental parathyroid gland resection is venous thromboembolism, pulmonary embolism, and MI.
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closely associated with permanent hypoparathyroidism, In cases where thyroid surgery affects the blood supply to
whereas auto-transplantation more commonly leads to the parathyroid glands due to improper handling, vascular
transient dysfunction. injury, or thermal-induced vascular spasms, dalteparin, as
In the present study, 0.1 mL of a nano-carbon an anticoagulant, can help prevent the formation of vascular
suspension was injected into both thyroid lobes, and blood clots in the parathyroid glands. This facilitates a
surgery was initiated 3 min later. This nanotracer exhibits quicker recovery of blood supply to the parathyroid glands,
rapid lymphatic uptake, strong lymphatic tropism, and a consequently aiding in the faster restoration of parathyroid
high staining rate, thereby facilitating the identification function. Current clinical studies have demonstrated
of parathyroid tissue. Bipolar electrocoagulation was that the use of low-molecular-weight heparin does not
employed to avoid excess heat conduction from energy increase the post-operative bleeding rate, while also being
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devices, thus reducing the risk of thermal injury to the effective in preventing thrombosis. In traditional Chinese
parathyroid glands and associated vessels. medicine, hypoparathyroidism is believed to be primarily
caused by Yang deficiency. Therefore, treatment often
4.3. Anticoagulant therapy for post-operative involves the use of some traditional Chinese medicine
parathyroid dysfunction that regulates the liver and qi, improves the function of
According to statistics, 60% of patients with post-operative qi and blood, nourishes Yin, addresses deficiency heat,
PTH levels <12 pg/mL may experience symptoms of replenishes vitality, and regulates the immune system to
low calcium within 24 h. Hypocalcemia destabilizes the treat the patient. The Shutong pill is composed of various
excitability of neuromuscular cells, leading to early perioral Chinese medicinal ingredients. Square yellow cypress
numbness, tingling, limb muscle stiffness, and, in severe clears heat, dries dampness, and promotes detoxification.
cases, spasms, convulsions, laryngospasm, and asphyxia. Tylospleen helps with dampness and depression, while
The most effective treatment for acute hypocalcemia is a Astragalus tonifies qi, promotes diuresis, and reduces
rapid intravenous infusion of 10 – 20 mL of 10% calcium swelling. Honeysuckle clears away heat and detoxifies;
gluconate, along with the initiation of oral calcium coix seed strengthens the spleen, stops diarrhea, removes
carbonate and activated Vitamin D to increase calcium bi, and discharges pus. White peony root nourishes Yin
absorption in the gut. Continuous serum biochemistry is and provides pain relief, while Angelica moistens the
used to monitor PTH and calcium levels during medication intestines, promotes blood circulation, and removes blood
administration to avoid adverse reactions resulting from stasis. Leech helps resolve stasis, Xuanshen nourishes Yin,
low calcium concentrations. This aggressive prophylactic and Shengjin clears heat, cools the blood, and detoxifies.
calcium supplement is highly effective and allows more These ingredients promote blood circulation, remove
than two-thirds of patients to recover within a month. blood stasis, relieve pain, and have anti-inflammatory
However, it poses a risk of overdose, as the required dose effects without the risk of bleeding. They are also effective
is highly individualized. Continuous calcium infusion in anticoagulation and thrombolysis. Mailuoshutong
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can lead to hypercalcemia and cerebral calcification in a pills are relatively mild traditional Chinese medicines with
very small number of patients, causing seizures. Increased anticoagulant properties that improve circulation and have
urinary calcium excretion may accelerate renal calcium vasodilatory effects. Relevant studies have indicated that
deposition, resulting in urinary stones, renal dysfunction, Mailuoshutong capsules are highly effective in treating
and other adverse reactions, which can significantly affect conditions such as deep vein thrombosis, diabetic foot,
the future quality of life of patients. 4 arterial occlusive disease, and thromboangiitis obliterans.

Volume 9 Issue 1 (2025) 210 doi: 10.36922/ejmo.8105