Page 214 - EJMO-9-1

Eurasian Journal of Medicine and
Oncology Anticoagulant therapy on parathyroid

• Dalteparin (Manufacturer: Vetter Pharma-Fertigung (2) Lab values: Serum calcium and PTH restored to
GmbH & Co. KG; 2500 IU, administered once daily normal or near normal ranges.
[qd] by intrahepatic injection [ih]).
• Vitamin D calcium chewable tablets, with the dosage 2.6.2. Valid
calculated based on whether patients presented (1) Clinical improvement: Partial relief of hypocalcemia
with clinical hypocalcemia symptoms, including symptoms.
perioral numbness, numbness in the hands and feet, (2) Lab values: Serum calcium and/or PTH remained mildly
carpopedal spasms, or convulsions ). or moderately below the normal range but showed
5,6
• Calcitriol (Manufacturer: Zhengda Pharmaceutical meaningful improvement compared to baseline.
Co., Ltd.; 1 capsule, taken twice daily [bid], orally).
2.6.3. Invalid
Meanwhile, MaiLuoShuTong pills were taken orally for
up to 3 months; if PTH levels returned to normal before (1) Clinical improvement: Minimal or no reduction in
3 months, the pills could be discontinued. Dalteparin was hypocalcemia symptoms.
administered starting on the first post-operative day and (2) Lab values: Serum calcium and PTH remained near or
continued for 15 days. The 110 patients in the control group, below their pre-operative levels, with little evidence of
who also experienced decreased parathyroid function after recovery.
surgery, received Vitamin D calcium chewable tablets and
calcitriol starting on post-operative day 1. 3. Results
2.4. Observation indicators 3.1. General information
The normal standard for PTH level was set to 12 pg/mL All the measurement data conformed to a normal
and a diversion rate of <15 mL was applied. Values and distribution. As shown in Table 1, the mean age
th
normal proportions were calculated on the 1 , 3 , 5 , 15 , of the patients in the anticoagulation group was
rd
st
th
th
30 , 90 and 180 days. Serum PTH and calcium levels 48.15 ± 13.61 years, and the mean age of the control group
th
th
were monitored on days 1, 3, 5, 9, 15, and 21. Venous was 47.92 ± 14.23 years. There was no significant difference
blood (2 mL) was extracted in the morning. PTH was between the two groups (P = 0.90). There was also no
detected through the chemiluminescent microparticle significant difference in sex distribution between the
immunization method, and serum calcium levels were anticoagulation group and the control groups (P = 0.78).
detected using the phenolphthalein method. The measured The surface areas of the patients in both groups were not
values were accurately recorded. significantly different (P = 0.86). Among the tumor sizes,
119 tumors were <1 cm and 32 tumors were >1 cm in the
2.5. Statistical analysis anticoagulation group. In the control group, 86 tumors
All the data were analyzed with SPSS 22.0 software were <1 cm and 24 tumors were >1 cm. There was no
(International Business Machines Corporation, United significant difference between the two groups (P = 0.90).
States of America). The normality of the distribution Lymph node enlargement in area VI was detected in
of the measurement data were determined through the 13 patients in the anticoagulation group and 11 patients
one-sample K-square test, and normally distributed in the control group. No enlargement was observed in
measurement data are expressed as mean ± standard 138 patients in the anticoagulation group and 99 in the
deviation (x ± s). Paired t-tests were used to compare the control group, with no significant difference between the
post-operative PTH levels, mean neck flow rate, and neck two groups (P = 0.70). Stage I tumors were observed in
drainage removal time between groups to determine the 145 patients in the anticoagulation group and 105 patients
incidence of hypoparathyroidism on days 3, 5, 15, 30, 90, in the control group, whereas Stage II tumors were found
and 180. A P < 0.050 was considered statistically significant. in 6 patients in the anticoagulation and 5 patients in the
control group, with no significant difference between the
2.6. Efficacy evaluation criteria two groups (P = 0.82).
To evaluate treatment outcomes, each patient was assigned
to one of three categories based on clinical symptoms, 3.2. Comparisons of the number of lymph nodes
serum calcium, and PTH levels: in the intraoperative central area, PTH level,
mean drainage rate, and removal time on the first
2.6.1. Effective post-operative day
(1) Clinical improvement: Marked alleviation or complete As shown in Table 2, there were 3.76 ± 2.40 lymph nodes
resolution of hypocalcemia symptoms. dissected in the central area of the anticoagulation group.

Volume 9 Issue 1 (2025) 206 doi: 10.36922/ejmo.8105