Page 212 - EJMO-9-1

Eurasian Journal of Medicine
and Oncology

ORIGINAL RESEARCH ARTICLE
Clinical effect of MaiLuoShuTong pills combined

with dalteparin on parathyroid function recovery
after total thyroidectomy

Jiaqi Liu , Jun Chu, Mengmeng Chen, and Yu Ding*

Department of Breast and Thyroid Surgery, Zibo Central Hospital, Zibo, Shandong Province, China

Abstract

The present study aims to investigate the therapeutic efficacy and safety of the
combined use of MaiLuoShuTong pills and dalteparin in managing post-operative
hypoparathyroidism following total thyroidectomy. Data from 928 thyroid cancer
patients who underwent total thyroidectomy and lymph node dissection at the
Department of Breast and Thyroid Surgery, Zibo Central Hospital, between May
2021 and October 2022, were retrospectively analyzed. Among these patients, 261
experienced post-operative decreased parathyroid function. Of these, 151 patients
(anticoagulant group) received MaiLuoShuTong pills combined with dalteparin
anticoagulant therapy and calcium supplementation starting on post-operative day
1. The remaining 110 patients (control group) received only post-operative calcium
*Corresponding author: supplementation. The incidence of permanent hypoparathyroidism, the average
Yu Ding time to normalization of parathyroid function, and the average post-operative days
(dingyu824@sina.com)
until Hemovac removal and total drainage volume were recorded. Treatment efficacy,
Citation: Liu J, Chu J, Chen M, as well as serum parathyroid hormone (PTH) and calcium levels were compared
Ding Y. Clinical effect of between the two groups. The anticoagulant group had a 0% incidence of permanent
MaiLuoShuTong pills combined with
dalteparin on parathyroid function hypoparathyroidism, which was significantly lower than the 3.64% incidence in
recovery after total thyroidectomy. the control group (P < 0.05). There were no significant differences in the number
Eurasian J Med Oncol. 2025; of post-operative days until Hemovac removal (P = 0.28) or total drainage volume
9(1):204-213.
doi: 10.36922/ejmo.8105 (P = 0.59) between the two groups. Parathyroid function in the anticoagulant group
recovered significantly faster at 15, 30, 90, and 180 days compared to the control
Received: December 20, 2024
group (P < 0.05). Post-operative hypoparathyroidism is a common complication
Revised: January 15, 2025 after total thyroidectomy. The combined use of MaiLuoShuTong pills and dalteparin
Accepted: January 22, 2025 anticoagulant therapy can promote parathyroid function recovery, improve PTH and
serum calcium levels, enhance clinical efficacy, reduce the incidence of permanent
Published online: February 12,
2025 functional impairment, and ensure a safe and reliable post-operative treatment
outcome.
Copyright: © 2025 Author(s).
This is an Open-Access article
distributed under the terms of the
Creative Commons Attribution Keywords: Thyroid malignancy; Total thyroid resection; Hypoparathyroid function;
License, permitting distribution, Anticoagulation therapy; Infarction of the parathyroid gland
and reproduction in any medium,
provided the original work is
properly cited.
Publisher’s Note: AccScience
Publishing remains neutral with 1. Background
regard to jurisdictional claims in
published maps and institutional The incidence of thyroid cancer has risen rapidly in recent years, making it one of the
1,2
affiliations. fastest-increasing malignancies worldwide. Recent epidemiological data indicate

Volume 9 Issue 1 (2025) 204 doi: 10.36922/ejmo.8105