Page 215 - EJMO-9-1

Eurasian Journal of Medicine and
Oncology Anticoagulant therapy on parathyroid

There was no significant difference in the number of lymph Hemovac in the anticoagulation group was 4.17 ± 0.79 days,
nodes dissected in the central area. On the 1 day, the and the average daily diversion rate in the control group
st
PTH level was 4.57 ± 3.08 pg/mL. In the control group, was 4.06 ± 0.82 days. There was no significant difference
the PTH level was 4.59 ± 3.17 pg/mL. There was no (P = 0.28).
significant difference between the two groups (P = 0.96).
The average daily induced flow rate in the anticoagulant 3.3. Parathyroid gland recovery
group was 23.90 ± 3.56 mL, and the average daily induced The incidence of permanent hypoparathyroidism was
flow rate in the control group was 24.13 ± 3.42. There was 0% in the anticoagulant group compared to 3.64% in
no significant difference. The mean days of removal of the control group. As shown in Table 3, the proportion
of patients in the anticoagulant group who returned to
Table 1. Baseline characteristics normal levels on post-operative day 3 (P = 0.77) or day
5 (P = 0.46) was not significantly different. However, on
Clinical characteristics Anticoagulant Control P
group (n = 151) group (n = 110) post-operative days 15, 30, 90, and 180, the proportion
Age (year) 48.15 ± 13.61 47.92 ± 14.23 0.90 of patients returning to normal levels was significantly
greater in the anticoagulant group than in the control
Sex
group (P < 0.05).
Men 51 39 0.78
Women 100 71 3.4. Comparison of PTH indices at different post-
Body surface area (m ) 1.65 ± 0.15 1.64 ± 0.15 0.86 operative time points
2
Tumor size After surgery, PTH levels varied significantly between the
<1 cm 119 86 0.90 two groups. Over time, both groups showed significant
More than 1 cm 32 24 increases in PTH levels. However, the anticoagulant group
Usage of color Doppler ultrasound a exhibited significantly greater PTH levels compared to the
control group (P < 0.05), as shown in Table 4.
Yes 13 11 0.70
No 138 99 3.5. Comparison of serum calcium indices between
the two groups at different post-operative time
Tumor type
Papillary thyroid 151 110 1.00 points
carcinoma After surgery, the serum calcium indices varied significantly
Other types of thyroid 0 0 1.00 between the two groups. Both groups demonstrated
cancer significant increases in serum calcium levels with increasing
Tumor stage post-operative time. However, the serum calcium
Stage I 145 105 0.82 concentration in the anticoagulant group was significantly
Stage II 6 5 greater than that in the control group (P < 0.05), as shown
Microcarcinoma characteristics in Table 5.
Unilateral microscopic 40 23 0.36 3.6. Comparison of treatment efficacy between the
carcinoma combined two groups
with BRAF V600E gene
mutation After the intervention, the efficacy of the two regimens
Bilateral microcarcinoma 79 63 0.36 differed significantly, with the treatment effect significantly
Notes: To assess the presence of area VI lymph node enlargement. better in the anticoagulant group than in the control group
a
Abbreviation: BRAF: Serine/threonine-protein kinase B-raf. (P < 0.05), as shown in Table 6 and Figure 1.
Table 2. Surgical characteristics

Surgical characteristics Anticoagulant Control group t P
group (n = 151) (n = 110)
Number of lymph node dissection in the central area 3.76 ± 2.40 3.59 ± 2.20 0.585 0.559
Daily flow rate (mL) 23.90 ± 3.56 24.13 ± 3.42 −0.524 0.601
Mean days of removal of Hemovac (day) 4.17 ± 0.79 4.06 ± 0.81 1.099 0.273
PTH level (pg/mL) 4.57 ± 3.08 4.59 ± 3.17 −0.051 0.959
Abbreviation: PTH: Parathyroid hormone.

Volume 9 Issue 1 (2025) 207 doi: 10.36922/ejmo.8105