Page 253 - EJMO-9-1

Eurasian Journal of Medicine

and Oncology

ORIGINAL RESEARCH ARTICLE
Health-related quality of life, somatosensory

amplification, and perceived stress in autosomal
dominant polycystic kidney disease: An

observational study

Zekeriya Temircan * and Müge Artar †
†
Department of Psychology, Faculty of Humanities, Cappadocia University, Nevsehir, Türkiye

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder
characterized by the development of fluid-filled cysts in the kidneys, which can
lead to the gradual loss of kidney function over time. This study aimed to explore
the health-related quality of life (HRQOL), levels of somatosensory amplification,
and perceived stress in patients with ADPKD. A total of 48 patients with ADPKD
† These authors contributed equally
to this work. and 50 healthy volunteers aged 18 and older participated in this study. All patients
participating in the study were assessed using the 12-item Short Form Healthy Survey
*Corresponding author:
Zekeriya Temircan version 2, the Somatosensory Amplification Scale (SSAS), and the Perceived Stress
(zekeriya.temircan@kapadokya. Scale (PSS). The scores of the SSAS and the PSS for the patient group were higher but
edu.tr) the HRQOL score was lower than those for the healthy group. Upon a simple linear
Citation: Temircan Z, Artar M. regression analysis, the effect of duration of disease in the polycystic kidney disease
Health-related quality of life, (PKD) group on HRQOL was 13.4% and the effect of level of perceived stress on the
somatosensory amplification, and
perceived stress in autosomal somatosensory amplification was 18.4%. The patients in the PKD group exhibited
dominant polycystic kidney disease: higher levels of somatosensory amplification and level of perceived stress but
An observational study. Eurasian J lower levels of HRQOL than the healthy group. The patients with ADPKD experience
Med Oncol. 2025;9(1):245-256.
doi: 10.36922/ejmo.7550 significantly higher levels of somatosensory amplification and perceived stress,
along with lower HRQOL, compared to healthy individuals. The findings highlight
Received: December 14, 2024
the negative psychosocial burden associated with ADPKD, with disease duration
1st revised: January 9, 2025 affecting HRQOL and perceived stress influencing somatosensory amplification.
2nd revised: February 8, 2025
Accepted: February 25, 2025 Keywords: Polycystic kidney; Stress; Somatosensory amplification; Health-related
Published online: March 7, 2025 quality of life
Copyright: © 2025 Author(s).
This is an Open-Access article
distributed under the terms of the
Creative Commons Attribution 1. Introduction
License, permitting distribution,
and reproduction in any medium, Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent
provided the original work is inherited kidney disorder globally and constitutes a major cause of end-stage renal
properly cited. disease. ADPKD is a prevalent genetic condition, estimated to impact approximately
1
Publisher’s Note: AccScience 10 million individuals globally, making it one of the most common inherited kidney
Publishing remains neutral with disorders. The number of ADPKD patients aged 18 and over in Turkey is estimated
2
regard to jurisdictional claims in
published maps and institutional to range between approximately 62,000 and 155,000. Notable complications associated
affiliations. with ADPKD include hypertension, chronic pain, recurrent urinary tract infections,

Volume 9 Issue 1 (2025) 245 doi: 10.36922/ejmo.7550