Page 256 - EJMO-9-1

Eurasian Journal of
Medicine and Oncology Quality of life, somatosensory amplification, and stress in ADPKD

emotional challenges such as anxiety and depression, 50 in each group. A total of 48 PKD patients and 50 healthy
which can further compromise self-management and volunteers aged 18 years and older showed interest to
overall quality of life. participate in this study. Those who participated in the study
Despite these potential links, research examining the signed the informed consent form and then completed the
direct effects of perceived stress on PKD progression survey questionnaires. Subjects in the study were randomly
remains limited. Longitudinal studies investigating how selected. The study was conducted by face-to-face interviews
stress interacts with biological and behavioral factors with individuals. Subjects in this study were selected according
to influence renal outcomes in PKD are needed. Such to the following criteria: no missing data for perceived stress;
research could inform the development of targeted stress- diagnosed with PKD; aged 18 years or above; and completion
management interventions aimed at improving both of scales. Finally, a total of 98 subjects were included in the
physiological outcomes and patient-reported quality-of- present study. All participants provided informed consent
life measures in individuals with PKD. Understanding prior to inclusion. The study was carried out in compliance
these relationships is vital for enhancing comprehensive with the principles of the Declaration of Helsinki.
care and mitigating the substantial burden of this chronic 2.2. Data collection tools
genetic condition.
2.2.1. Socio-demographic form
2. Materials and methods
The researcher prepared the questionnaire to obtain
2.1. Sample information from the participants. Socio-demographic
characteristics of the patients and healthy volunteers were
This study was conducted at the Nephrology Clinic of obtained by using this questionnaire.
Erciyes University Research Hospital as a single-center
investigation. A cross-sectional, descriptive, and survey- 2.2.2. 12-item Short Form Healthy survey version 2
based research design was employed. Inclusion criteria of (SF-12v2)
this study include: (1) a confirmed diagnosis of ADPKD
based on family history and clinical findings, (2) provision The Health Questionnaire survey version 2 form is a
of signed informed consent, and (3) being over 18 years questionnaire that consists of 12 items and is widely used to
of age. Exclusion criteria comprise: use of psychotropic measure HRQOL. This version of short and practical form
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medications, the presence of other conditions that could was developed by Ware et al. With this form, the scores of
cause renal cyst formation in the patient or their family, the physical and mental components of the participants can
pregnancy, cerebrovascular disease, dementia, severe head be obtained. The form, which has 8 sub-scales, measures the
trauma resulting in cognitive impairment, alcohol use participants’ general health; physical function; role – physical,
disorder, and a diagnosis of intellectual disability. bodily pain, vitality; and role – emotional, mental health,
and social function. Most items are evaluated with Likert-
In this study, a healthy group was matched to the patient type questions except for some items and data from the last
group based on specific criteria to ensure comparability. 4 weeks are taken into consideration. Sub-scales evaluate
All participants in the healthy group were required to be health between 0 and 100, with 0 indicating poor health and
18 years of age or older. Efforts were made to match the 100 indicating good health. Turkish validity and reliability
groups in terms of age, gender, and basic sociodemographic study was done by Koçyiğit et al. A shorter form, SF-12 Brief
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characteristics. To minimize confounding variables, Health Scale, was created by taking 12 different items from 8
individuals in the healthy group were excluded if they different sub-headings of SF-36. Comparisons of SF-12 and
had a history of chronic medical conditions, including SF-36 have been made and it has been reported that SF-12
renal, cardiovascular, or psychiatric disorders. In addition, is more advantageous in terms of its ease of application
participants using psychotropic medications or with a and shorter completion time. The Cronbach’s alpha values
history of substance use disorder were not included in the calculated for the internal consistency of the scale were 0.70
healthy group. These criteria were implemented to ensure in the physical functionality area, 0.72 in the physical role
that differences observed between the groups could be area, 0.67 in the pain area, 0.68 in the general health area,
more accurately attributed to the presence of ADPKD. 0.70 in the mental role area, and 0.70 in the mental role area,
The data were collected from each participant through 0.66 for social functionality, and 0.70 for vitality.
different survey questionnaires. G* power analysis was done
to calculate the sample size. The alpha and beta errors were 2.3. The Somatosensory Amplification Scale (SSAS)
stated, respectively, as 0.05 and 0.20. The minimum number The SSAS is a scale used to measure the sensitivity to
of patients needed to obtain 80% power was calculated as disturbing bodily sensations. It consists of 10 questions

Volume 9 Issue 1 (2025) 248 doi: 10.36922/ejmo.7550