Page 260 - EJMO-9-1

Eurasian Journal of
Medicine and Oncology Quality of life, somatosensory amplification, and stress in ADPKD

also plays a significant role, as female participants health aspects. Although mental health components such
exhibit lower HRQOL scores compared to their male as emotional well-being and role emotional were also
counterparts (β = −0.265, p = 0.014). These factors lower in patients, these differences were not statistically
emerged as significant only in the regression analysis, significant, indicating a less pronounced effect on mental
likely because they function as moderating variables, health. In addition, patients reported higher levels of
indirectly influencing the relationship between perceived perceived stress (PSS) and somatosensory amplification
stress (PSS), somatosensory amplification (SSAS), and (SSAS), which were significantly correlated with lower
HRQOL. Furthermore, higher levels of perceived stress, HRQOL scores, underscoring the psychological strain
as measured by the PSS, are significantly associated with associated with the disease. Multivariate regression analysis
reduced HRQOL scores (p < 0.001). Similarly, increases in further revealed that age and gender significantly influence
the SSAS scores are linked to a notable decline in HRQOL HRQOL, with older age and female gender associated with
score (p < 0.001). In contrast, total education time does lower scores. In contrast, educational background did not
not show a significant impact on HRQOL, suggesting that significantly impact HRQOL, suggesting that the disease’s
variations in educational background do not substantially effects on quality of life are more related to physical and
affect the HRQOL in this sample (β = 0.105, p = 0.177). psychological factors rather than educational attainment.
When controlling for other variables, education did not These results emphasize the need to address both physical
exhibit a significant effect on HRQOL, which contrasts symptoms and psychological factors in managing PKD to
with findings reported in the existing literature. These improve patients’ overall well-being.
findings underscore the importance of psychological PKD adversely affects the health-related quality and
factors, such as stress and somatosensory amplification, in functionality of females during their productive years.
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influencing the quality of life, while demographic factors Many studies have been conducted to examine the
such as gender and age also play critical roles. different psychosocial factors of patients with PKD. For
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A multivariate regression analysis was conducted instance, one study demonstrated the balance between
to eliminate the potential confounding effect of gender disease, health-related quality, and resilience can predict
on the dependent variable. Gender, age, PSS score, and overall health. Compared to the healthy group, adults with
SSAS score were included as independent variables in the CKD reported poor coping skills and decreased resiliency
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analysis. Thus, the effect of gender on other variables was factors. Report from the existing literature demonstrate
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controlled, and the true effects on the dependent variable a lower quality of life for individuals with CKD. Another
were more accurately assessed (Table 5). study reported that female and obese individuals are
exposed to higher level of stress in everyday life, which
4. Discussion potentially aggravates their HRQOL. 6
The findings of the present study highlight the multifaceted A review of the literature reveals that hypertension
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impact of PKD on patients’ quality of life, with significant is the most prevalent clinical manifestation of PKD.
physical and psychological dimensions. Patients with PKD Hypertension has a deleterious impact on morbidity,
exhibit notably lower scores in various sub-domains of mortality, and HRQOL in this patient group, and it
3
HRQOL, particularly in physical functioning, general accelerates the progression to renal failure. Furthermore,
health, and vitality, compared to the healthy group. This it elevates the likelihood of hypertension-related
suggests that the disease substantially diminishes physical cardiovascular incidents and renal failure in this patient
cohort. In light of these observations, it can be posited
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Table 5. Multivariate regression analysis results that this patient group may exhibit elevated levels of
anxiety, depression, stress, and diminished quality of
Independent variables B SE Beta T p life. The present study revealed a correlation between the
Age −0.152 0.067 −0.210 −2.268 0.029* duration of the disease and a negative PSS score in the PKD
Gender −3.472 1.385 −0.265 −1.507 0.014* group. Patients with PKD have been found to experience
PSS −0.341 0.059 −0.482 −5.780 <0.001** elevated levels of disease-associated pain, discomfort,
SSAS −0.215 0.048 −0.318 −4.479 <0.001** fatigue, emotional distress, and impaired mobility, which
collectively impact their HRQOL.
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Total education time 0.105 0.077 0.105 1.364 0.177
Constant 30.812 4.562 - 6.757 <0.001** A substantial body of research has demonstrated a
Notes: *p<0.05; **p<0.01. correlation between pain and pain perception in patients
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Abbreviations: HRQOL: Health-related quality of life; PSS: Perceived with PKD. However, an assessment of the level of
Stress Scale; SSAS: Somatosensory amplification scale. somatosensory amplification in this patient group is

Volume 9 Issue 1 (2025) 252 doi: 10.36922/ejmo.7550