Page 259 - EJMO-9-1

Eurasian Journal of
Medicine and Oncology Quality of life, somatosensory amplification, and stress in ADPKD

Table 3. Correlation results of PKD group and healthy group
All participants (n=98) HRQOL PSS SSAS
Duration of disease r=0.148, p=0.162 r=−0.321, p=0.032* r=0.255, p=0.014*
HRQOL 1 r=0.438, p=0.622** r=0.408, p=0.182**
PSS 1 r=0.638, p=0.107
SSAS 1
PKD patients (n=50) HRQOL PSS SSAS
Duration of disease r=−0.102, p=0.364 r=−0.298, p=0.013* r=0.864, p=0.152
HRQOL 1 r=0.122, p=0.680** r=0.286, p=0.038*
PSS 1 r=0.692, p=0.001**
SSAS 1
Notes: **Correlation is significant at p<0.01; *correlation is significant at p<0.05.
Abbreviations: HRQOL: Health-related quality of life; PKD: Polycystic kidney disease; PSS: Perceived Stress Scale; SSAS: Somatosensory amplification
scale.

Table 4. Effects of disease duration and perceived stress level (R = 0.263), explaining 13.4% of the variance in HRQOL
on HRQOL and SASS in PKD group (R = 0.134), with the F statistic being significant (F = 3.866).
2
(A) Effects of disease duration and perceived stress level on HRQOL In Model 2, the level of perceived stress (PSS) was
Independent variable Model 1 found to have a significant positive effect on HRQOL, with
Β a β of 0.247 (p = 0.024). This suggests that higher perceived
Duration of disease −0.512 stress is associated with lower HRQOL in the PKD group.
Multiple regression analysis identified a significant impact
R 0.263 of perceived stress (PSS) on HRQOL, despite the absence
R 2 0.134 of a significant simple correlation. This discrepancy arises
F 3.866 because the regression model accounts for confounding
p 0.012* variables such as age and gender, thereby uncovering the
Model 2 true relationship between perceived stress and quality
Β of life. The model had a moderate level of correlation
PSS 0.247 (R = 0.368) and explained 10.2% of the variance in HRQOL
2
R 0.368 (R = 0.102), with the F statistic indicating statistical
significance (F = 4.288).
R 2 0.102
F 4.288 In addition, the effect of perceived stress on
p 0.024* somatosensory amplification (SSAS) was explored in the
(B) Effect of perceived stress level on SSAS PKD group. In Model 1, perceived stress (PSS) was found
to have a significant positive effect on SSAS, with a β of
Independent variable Model 1 0.365 (p < 0.001), suggesting that higher perceived stress
Β is associated with increased somatosensory amplification.
PSS 0.365 The model demonstrated a strong correlation (R = 0.552),
R 0.552 explaining 18.4% of the variance in SSAS (R = 0.184),
2
R 2 0.184 with the F statistic indicating a highly significant result
F 9.355 (F = 9.355). Overall, the findings highlight the significant
p <0.001** roles of both the duration of disease and the level of
Notes: *p<0.05; **p<0.01. In part (A): Model 1 – the effect of duration perceived stress in influencing HRQOL and somatosensory
of disease on HRQOL; Model 2 – the effect of perceived stress level on amplification in patients with PKD.
HRQOL. In part (B): Model 1 – the effect of perceived stress level on The results of the multivariate regression analysis
SSAS. indicate that age has a significant negative relationship
Abbreviations: PKD: Polycystic kidney disease; PSS: Perceived Stress
Scale; HRQOL: Health-Related Quality of Life; SSAS: Somatosensory with HRQOL scores, with an increase in age leading to
Amplification Scale. a decrease in HRQOL (β = −0.210, p = 0.026). Gender

Volume 9 Issue 1 (2025) 251 doi: 10.36922/ejmo.7550