Page 204 - EJMO-9-2

Eurasian Journal of
Medicine and Oncology Vitamin D and HNC: Causal association

although a causal link between Vitamin D levels and HNC Grandis JR. Head and neck squamous cell carcinoma. Nat
risk was established in this study, data limitations hindered Rev Dis Primers. 2020;6(1):92.
a deeper investigation into the relationship. doi: 10.1038/s41572-020-00224-3

5. Conclusions 3. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics
2020: GLOBOCAN estimates of incidence and mortality
Overall, this study identified the causality of Vitamin D for worldwide for 36 cancers in 185 countries. CA A Cancer J
HNC risk using MR methods. Vitamin D supplementation Clin. 2021;71(3):209-249.
may reduce the HNC risk, providing fresh perspectives on doi: 10.3322/caac.21660
cancer prevention and therapy.
4. Guo K, Xiao W, Chen X, Zhao Z, Lin Y, Chen G. Epidemiological
Acknowledgments trends of head and neck cancer: A population-based study.
Biomed Res Int. 2021;2021:1738932.
We appreciated all the genetics consortiums for making
the GWAS summary data publicly available. doi: 10.1155/2021/1738932
5. Pu Y, Zhu G, Xu Y, et al. Association between vitamin D
Funding exposure and head and neck cancer: A systematic review
with meta-analysis. Front Immunol. 2021;12:627226.
This research was supported by the National Natural
Science Foundation of China (Grant No. 81973805); doi: 10.3389/fimmu.2021.627226
the Zhejiang Provincial Project for the key discipline 6. Holick MF. Vitamin D deficiency. N Engl J Med.
of traditional Chinese Medicine (Yong Guo, no. 2017- 2007;357(3):266-281.
XK-A09); and the Academic Inheritance and Specialty doi: 10.1056/NEJMra070553
Construction of Famous and Elderly Chinese Medicine
Practitioners in Zhejiang Province (2A11543). 7. Rebelos E, Tentolouris N, Jude E. The role of vitamin D in
health and disease: A narrative review on the mechanisms
Conflict of interest linking vitamin D with disease and the effects of
supplementation. Drugs. 2023;83(8):665-685.
The authors declare no conflicts of interest.
doi: 10.1007/s40265-023-01875-8
Author contributions 8. Fleet JC, DeSmet M, Johnson R, Li Y. Vitamin D and

Conceptualization: Xiaosong Ru cancer: A review of molecular mechanisms. Biochem J.
Formal analysis: Xiaosong Ru, Ziying Su 2012;441(1):61-76.
Investigation: Ziying Su doi: 10.1042/BJ20110744
Methodology: Xiaosong Ru 9. Starska-Kowarska K. Role of vitamin D in head and neck
Supervision: Yong Guo cancer-immune function, anti-tumour effect, and its impact
Writing–original draft: Xiaosong Ru on patient prognosis. Nutrients. 2023;15(11):2592.
Writing–review & editing: Ziying Su, Yong Guo doi: 10.3390/nu15112592
Ethics approval and consent to participate 10. Arayici ME, Basbinar Y, Ellidokuz H. Vitamin D intake,
serum 25-hydroxyvitamin-D (25(OH)D) levels, and cancer
Not applicable. risk: A comprehensive meta-meta-analysis including meta-
analyses of randomized controlled trials and observational
Consent for publication epidemiological studies. Nutrients. 2023;15(12):2722.
Not applicable. doi: 10.3390/nu15122722
Availability of data 11. Lappe JM, Travers-Gustafson D, Davies KM, Recker RR,
Heaney RP. Vitamin D and calcium supplementation
All GWAS datasets utilized in this study can be accessed reduces cancer risk: Results of a randomized trial. Am J Clin
through online databases. (https://gwas.mrcieu.ac.uk/). Nutr. 2007;85(6):1586-1591.

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