Page 205 - EJMO-9-2

Eurasian Journal of
Medicine and Oncology Vitamin D and HNC: Causal association

13. Afzal S, Bojesen SE, Nordestgaard BG. Low plasma 24. Howe LJ, Nivard MG, Morris TT, et al. Within-sibship
25-hydroxyvitamin D and risk of tobacco-related cancer. genome-wide association analyses decrease bias in estimates
Clin Chem. 2013;59(5):771-780. of direct genetic effects. Nat Genet. 2022;54(5):581-592.
doi: 10.1373/clinchem.2012.201939 doi: 10.1038/s41588-022-01062-7
14. Mäkitie A, Tuokkola I, Laurell G, et al. Vitamin D in 25. Bowden J, Del Greco MF, Minelli C, et al. Improving
head and neck cancer: A systematic review. Curr Oncol the accuracy of two-sample summary-data Mendelian
Rep. 2020;23(1):5. randomization: Moving beyond the NOME assumption. Int
J Epidemiol. 2019;48(3):728-742.
doi: 10.1007/s11912-020-00996-7
doi: 10.1093/ije/dyy258
15. Arem H, Weinstein SJ, Horst RL, et al. Serum
25-hydroxyvitamin D and risk of oropharynx and larynx 26. Slob EAW, Burgess S. A comparison of robust Mendelian
cancers in Finnish men. Cancer Epidemiol Biomarkers Prev. randomization methods using summary data. Genet
2011;20(6):1178-1184. Epidemiol. 2020;44(4):313-329.
doi: 10.1158/1055-9965.EPI-11-0153 doi: 10.1002/gepi.22295
16. Emdin CA, Khera AV, Kathiresan S. Mendelian 27. Bowden J, Davey Smith G, Burgess S. Mendelian
randomization. JAMA. 2017;318(19):1925-1926. randomization with invalid instruments: Effect estimation
and bias detection through Egger regression. Int J Epidemiol.
doi: 10.1001/jama.2017.17219 2015;44(2):512-525.
17. Burgess S, Davey Smith G, Davies NM, et al. Guidelines doi: 10.1093/ije/dyv080
for performing Mendelian randomization investigations:
Update for summer 2023. Wellcome Open Res. 2023;4:186. 28. Verbanck M, Chen CY, Neale B, Do R. Detection of
widespread horizontal pleiotropy in causal relationships
doi: 10.12688/wellcomeopenres.15555.3 inferred from Mendelian randomization between complex
18. Davies NM, Holmes MV, Davey Smith G. Reading traits and diseases. Nat Genet. 2018;50(5):693-698.
Mendelian randomisation studies: A guide, glossary, and doi: 10.1038/s41588-018-0099-7
checklist for clinicians. BMJ. 2018;362:k601.
29. Burgess S, Bowden J, Fall T, Ingelsson E, Thompson SG.
doi: 10.1136/bmj.k601 Sensitivity analyses for robust causal inference from
19. Dai Y, Chen Y, Pu Y, Jiang R. Circulating vitamin D Mendelian randomization analyses with multiple genetic
concentration and risk of 14 cancers: A bidirectional variants. Epidemiology. 2017;28(1):30-42.
Mendelian randomization study. J Cancer Res Clin Oncol. doi: 10.1097/EDE.0000000000000559
2023;149(17):15457-15467.
30. Orell-Kotikangas H, Schwab U, Österlund P, Saarilahti K,
doi: 10.1007/s00432-023-05322-9 Mäkitie O, Mäkitie AA. High prevalence of vitamin D
20. Lin T, Zhou F, Mao H, Xie Z, Jin Y. Vitamin D and idiopathic insufficiency in patients with head and neck cancer at
pulmonary fibrosis: A two-sample Mendelian randomization diagnosis. Head Neck. 2012;34(10):1450-1455.
study. BMC Pulm Med. 2023;23(1):309. doi: 10.1002/hed.21954
doi: 10.1186/s12890-023-02589-z 31. Deeb KK, Trump DL, Johnson CS. Vitamin D signalling
21. Zhang Z, Qiu S, Wang Z, Hu Y. Vitamin D levels and five pathways in cancer: Potential for anticancer therapeutics.
cardiovascular diseases: A Mendelian randomization study. Nat Rev Cancer. 2007;7(9):684-700.
Heliyon. 2024;10(1):e23674. doi: 10.1038/nrc2196
doi: 10.1016/j.heliyon.2023.e23674 32. Feldman D, Krishnan AV, Swami S, Giovannucci E,
22. Sanderson E, Davey Smith G, Windmeijer F, Bowden J. An Feldman BJ. The role of vitamin D in reducing cancer risk
examination of multivariable Mendelian randomization in and progression. Nat Rev Cancer. 2014;14(5):342-357.
the single-sample and two-sample summary data settings. doi: 10.1038/nrc3691
Int J Epidemiol. 2019;48(3):713-727.
33. Satake K, Takagi E, Ishii A, et al. Anti-tumor effect of vitamin
doi: 10.1093/ije/dyy262 A and D on head and neck squamous cell carcinoma. Auris
Nasus Larynx. 2003;30(4):403-412.
23. Jiang X, O’Reilly PF, Aschard H, et al. Genome-wide
association study in 79,366 European-ancestry individuals doi: 10.1016/s0385-8146(03)00091-9
informs the genetic architecture of 25-hydroxyvitamin D 34. Meier JD, Enepekides DJ, Poirier B, Bradley CA, Albala JS,
levels. Nat Commun. 2018;9(1):260.
Farwell DG. Treatment with 1-alpha, 25-dihydroxyvitamin
doi: 10.1038/s41467-017-02662-2 D3 (vitamin D3) to inhibit carcinogenesis in the hamster

Volume 9 Issue 2 (2025) 197 doi: 10.36922/ejmo.7099