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Eurasian Journal of
Medicine and Oncology ANGPTL8 upregulation in CRC with liver metastasis

Acknowledgments References

We would like to express our deepest gratitude to the PhD 1. Dekker E, Tanis PJ, Vleugels JL, Kasi PM, Wallace MB.
biotechnology team at Universitas Negeri Malang for their Colorectal cancer. Lancet. 2019;394(10207):1467-1480.
contributions to this research. We also extend our sincere doi: 10.1016/S0140-6736(19)32319-0
appreciation to our collaborators from the Division of 2. Xi Y, Xu P. Global colorectal cancer burden in 2020 and
Digestive Surgery, Department of Surgery, Faculty of Medicine, projections to 2040. Transl Oncol. 2021;14(10):101174.
Public Health and Nursing, Universitas Gadjah Mada, and
Dr. Sardjito from General Hospital Yogyakarta, Indonesia. doi: 10.1016/j.tranon.2021.101174
3. Li J, Ma X, Chakravarti D, Shalapour S, DePinho RA.
Funding Genetic and biological hallmarks of colorectal cancer. Genes
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This study was supported by the 2024 Universitas Negeri
Malang PNBP research grant (Contract number: 4.4.602/ doi: 10.1101/gad.348226.120
UN32.14.1/LT/2024). 4. Kuipers EJ, Grady WM, Lieberman D, et al. Colorectal
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There was no conflict of interest among all authors in this 5. Thanikachalam K, Khan G. Colorectal cancer and nutrition.
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Author contributions doi: 10.3390/nu11010164
Conceptualization: Hendra Susanto, Adeodatus Yuda Handaya 6. Brody H. Colorectal cancer. Nature. 2015;521(7551):S1.
Formal analysis: Hendra Susanto, Jerry Dwi Trijoyo doi: 10.1038/521S1a
Purnomo, Wira Eka Putra, Zulqarnain Mohamed 7. Lengauer C, Kinzler KW, Vogelstein B. Genetic instability in
Investigation: Hendra Susanto, Adeodatus Yuda Handaya, colorectal cancers. Nature. 1997;386(6625):623-627.
Moch Sholeh
Methodology: Hendra Susanto, Arum Linangkung, doi: 10.1038/386623a0
Sa’diyatul Rizqie Amaliyah Firdaus 8. Patel SG, Ahnen DJ. Colorectal cancer in the young. Curr
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Jerry Dwi Trijoyo Purnomo, Arum Linangkung, Moch doi: 10.1007/s11894-018-0618-9
Sholeh, Sa’diyatul Rizqie Amaliyah Firdaus 9. Zhou E, Rifkin S. Colorectal cancer and diet: Risk versus
Writing – review & editing: Adeodatus Yuda Handaya, prevention, is diet an intervention? Gastroenterol Clin North
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Ethics approval and consent to participate doi: 10.1016/j.gtc.2020.10.012
This clinical investigation was conducted in accordance with 10. Valderrama-Treviño AI, Barrera-Mera B, Ceballos-Villalva JC,
Montalvo-Javé EE. Hepatic metastasis from colorectal cancer.
the Declaration of Helsinki and received ethical approval Euroasian J Hepatogastroenterol. 2017;7(2):166-175.
from the Institutional Review Board of the Faculty of
Medicine, Universitas Gadjah Mada, Indonesia (Approval doi: 10.5005/jp-journals-10018-1241
number: KE/FK/0938/EC/2021). All participants provided 11. Martin J, Petrillo A, Smyth EC, et al. Colorectal liver
written informed consent before the study. metastases: Current management and future perspectives.
World J Clin Oncol. 2020;11(10):761-808.
Consent for publication
doi: 10.5306/wjco.v11.i10.761
All participants have provided written informed consent 12. Zhou H, Liu Z, Wang Y, et al. Colorectal liver metastasis:
before the study, which includes the use of their samples for Molecular mechanism and interventional therapy. Sig
further research purposes. In addition, the identities of the Transduct Target Ther. 2022;7(1):1-25.
participants have been deidentified to ensure confidentiality.
doi: 10.1038/s41392-022-00922-2
Availability of data 13. Weitz J, Koch M, Debus J, Höhler T, Galle PR, Büchler MW.
Colorectal cancer. Lancet. 2005;365(9454):153-165.
All the datasets used and/or analyzed during the current
study are available from the corresponding author upon a doi: 10.1016/S0140-6736(05)17706-X
reasonable request. 14. Heinz MC, Peters NA, Oost KC, et al. Liver colonization

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