Page 272 - EJMO-9-2

Eurasian Journal of
Medicine and Oncology ANGPTL8 upregulation in CRC with liver metastasis

diabetes mellitus (DM), four had hypertension, 19 reported The protein and mRNA expression levels of
a high-protein diet, and two had cardiovascular disease. In ANGPTL8 were elevated in tumors of CRC patients
the liver metastasis group, two patients had a history of DM, with liver metastasis compared to those without liver
one had hyperlipidemia, two had hypertension, six had a metastasis (Figures 2 and 3). Notably, parametric analysis
history of smoking, 15 patients reported a high-protein using Pearson’s product-moment correlation shows a
diet, and two had cardiovascular disease. No history of significant negative correlation between ANGPTL8
alcoholism or hepatitis was reported in either group. expression and BMI (Pearson’s correlation coefficient =
Table 1 shows the baseline characteristics of CRC −0.367, p≤0.05) (Table 2). In addition, univariate linear
patients with and without liver metastasis in CRC patients. regression analysis shows that ANGPTL8 expression
There are no significant differences (p≥0.05) observed correlates with BMI (Table 3). These results suggest that
between the two groups in age, systolic blood pressure, ANGPTL8 could serve as a significant predictor for BMI
diastolic blood pressure, hemoglobin, hematocrit, white (p≤0.05) and may contribute significantly to BMI changes
blood cells, red blood cells, platelet, fasting blood glucose in CRC patients.
levels, albumin, blood urea nitrogen, and creatinine levels. 4. Discussion
However, circulating fasting blood glucose, albumin,
platelet, and blood urea nitrogen levels were observed to be In this study, it was revealed that ANGPTL8 expression in
higher in CRC patients with liver metastasis. Interestingly, tumors of CRC patients with liver metastasis is different
body mass index (BMI), alanine aminotransferase, aspartate from those without metastasis. Interestingly, ANGPTL8
aminotransferase, and carcinoembryonic antigen levels
were significantly different between both groups (p≤0.05). Table 2. Univariate correlations with ANGPTL8 in all
participants
Table 1. Baseline characteristics of the study population Parameters ANGPTL8
across different groups Pearson’s correlation p-value
coefficient (r)
Parameters Groups Age (years) 0.114 0.535
Non-metastasis Metastasis
2
(n=20) (n=21) BMI (kg/m ) −0.367 0.039*
Age (years) 54.50±3.12 57.08±2.99 SBP (mmHg) 0.181 0.320
BMI (kg/m ) 23.41±1.19 18.92±0.49* DBP (mmHg) 0.236 0.194
2
SBP (mmHg) 123.15±2.43 123.33±4.32 Hemoglobin (g/dL) −0.325 0.069
DBP (mmHg) 78.10±1.99 79.33±2.23 Hematocrit (%) −0.340 0.057
3
Hemoglobin (g/dL) 11.38±0.47 11.63±0.47 WBC (10 /μL) 0.118 0.520
3
Hematocrit (%) 34.91±1.37 35.37±1.23 RBC (10 /μL) −0.156 0.395
3
WBC (10 /μL) 8.77±0.84 10.70±1.36 Fasting glucose level (mg/dL) 0.164 0.370
3
RBC (10 /μL) 4.38±0.12 4.22±0.14 Albumin (g/dL) −0.180 0.325
Fasting glucose level (mg/dL) 120.80±10.27 142.33±10.54 BUN (mg/dL) −0.137 0.454
Albumin (g/dL) 3.63±0.15 3.13±0.16 Creatinine (mg/dL) −0.160 0.383
3
BUN (mg/dL) 12.69±1.49 16.77±2.32 PLT (10 /μL) 0.004 0.981
Creatinine (mg/dL) 0.91±0.07 0.97±0.13 ALT (U/L) 0.214 0.240
PLT (10 /μL) 284.10±21.33 370.58±31.57 AST (U/L) 0.347 0.052
3
ALT (U/L) 11.65±1.74 28.25±5.12* CEA (μg/L) 0.053 0.774
AST (U/L) 21.35±4.51 47.92±10.71* Tumor 0.037 0.840
CEA (μg/L) 14.36±5.51 307.53±1.27* Nodes 0.195 0.285
Note: Data are presented as mean±SEM. Asterisk (*) indicates a Metastasis 0.211 0.245
significant difference between the metastasis and the non-metastasis Note: Asterisk (*) indicates a statistically significant correlation
group (p≤0.05), as determined by an independent sample t-test. (p≤0.05), as determined by Pearson’s product-moment correlation test.
Abbreviations: ALT: Alanine aminotransferase; AST: Aspartate Abbreviations: ALT: Alanine aminotransferase; AST: Aspartate
aminotransferase; BMI: Body mass index; BUN: Blood urea nitrogen; aminotransferase; BMI: Body mass index; BUN: Blood urea nitrogen;
CEA: Carcinoembryonic antigen; DBP: Diastolic blood pressure; CEA: Carcinoembryonic antigen; DBP: Diastolic blood pressure;
PLT: Platelet; RBC: Red blood cell; SBP: Systolic blood pressure; PLT: Platelet; RBC: Red blood cell; SBP: Systolic blood pressure;
WBC: White blood cell. WBC: White blood cell, ANGPTL8: Angiopoietin-like protein 8.

Volume 9 Issue 2 (2025) 264 doi: 10.36922/EJMO025080034