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Eurasian Journal of
            Medicine and Oncology                                    TCM regulates gut microbiota in pediatric MP pneumonia























































            Figure 1. Flowchart of the literature screening process for the treatment of mycoplasma pneumonia with traditional Chinese medicine modulating
            intestinal microbiota
            Abbreviation: CNKI: China National Knowledge Infrastructure

                                                               medicine combined group compared to the Western
                                                               medicine-only group. After excluding the study with high
                                                               heterogeneity,18 the analysis showed no heterogeneity
                                                               (p = 0.535, I  = 0.0%). The MD was −5.803 (95% CI: −6.938,
                                                                        2
                                                               −4.668,  Z  =  10.02,  p  <  0.05),  indicating  a  significant
                                                               reduction in IL-6 levels.
                                                               3.4.4. Time to resolution of pulmonary rales

            Figure 2. Bar chart of bias risk in relevant literature on the treatment of   Regarding the time to rale resolution, four studies were
            mycoplasma pneumonia based on intestinal microbiota using traditional   involved. 19,20,22,28  Significant heterogeneity was observed
                                                                                        2
            Chinese medicine                                   among the studies (p = 0.00, I  = 85.6%), so a random-
                                                               effects model was used (Figure 3D). A significant difference
            model was used (Figure 3C). The results indicated that IL-6   was observed in the time for rales to resolve between
            levels were significantly lower in the TCM and Western   the two groups (MD = −2.126, 95% CI: −2.718, −1.534,



            Volume 9 Issue 2 (2025)                         46                              doi: 10.36922/ejmo.8602
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