Page 59 - EJMO-9-2

Eurasian Journal of
Medicine and Oncology TCM regulates gut microbiota in pediatric MP pneumonia

Table 2. Names and sequential numbering of herbs
ID Medicinal herb name
(1) Ephedra sinica Stapf
(2) Amygdalus communis L.
(3) Gypsum fibrosum
(4) Glycyrrhiza uralensis Fisch.
(5) Morus alba L.
(6) Phragmites communis Trin.
(7) Anemarrhena asphodeloides Bge.
(8) Trichosanthes kirilowii Maxim.
(9) Houttuynia cordata Thunb.
Figure 7. Sensitivity analysis of the total clinical effectiveness rate of (10) Draba nemorosa L.
traditional Chinese medicine based on intestinal microbiota in the
treatment of Mycoplasma pneumoniae pneumonia (11) Pheretima aspergillum
Abbreviation: CI: Confidence interval. (12) Lonicera japonica Thunb.
(13) Curcuma aromatica Salisb.
microbiota significantly improved the clinical effectiveness (14) Forsythia suspensa (Thunb.) Vahl
rate in children with MPP (RR = 1.19, 95% CI: 1.13, 1.26). (15) Bombyx mori L.
Furthermore, the experimental group, as compared to the
control group, accelerated the resolution of rales in children (16) Bupleurum chinense DC.
by 2.126 days and significantly influenced IL-6 levels and (17) Pueraria lobata (Willd.) Ohwi
Bifidobacterium counts, indicating a clear treatment effect. (18) Asarum sieboldii Miq.
(19) Citrus aurantium L.
4.1. Significance of the study
(20) Paris polyphylla Smith var. chinensis (Franch.) Hara
This research aimed to confirm the potential effectiveness (21) Ilex pubescens Hook. et Arn.
and safety of Chinese medicine, modulated by gut flora, (22) Rheum palmatum L.
in treating MPP. M. pneumoniae is a primary pathogen (23) Fritillaria thunbergii Miq.
responsible for community-acquired pneumonia,
accounting for approximately 8 – 40% of children (24) Ophiopogon japonicus (L.f.) Ker-Gawl.
hospitalized with community-acquired pneumonia. (25) Scrophularia ningpoensis Hemsl.
Studies have indicated a decrease in the age of onset in (26) Rehmannia glutinosa (Gaertn.) Libosch. ex Fisch. et Mey.
children with M. pneumoniae, accompanied by refractory (27) Paeonia lactiflora Pall.
32
and multisystem complications, posing a significant (28) Mentha haplocalyx Briq.
threat to the life and health of children. In addition to (29) Stemona sessilifolia (Miq.) Miq.
common extrapulmonary complications, M. pneumoniae (30) Scutellaria baicalensis Georgi
is emerging as a pathogen in acute pharyngitis in children,
causing persistent paroxysmal coughing often associated (31) Adenophora tetraphylla (Thunb.) Fisch.
with frequent pediatric pharyngitis, 33,34 although (32) Ginkgo biloba L.
further verification through extensive clinical trials is (33) Schisandra chinensis (Turcz.) Baill.
required. At present, macrolides are commonly used as (34) Trichosanthes kirilowii Maxim.
first-line drugs in Western medicine. However, Guo et (35) Ligusticum chuanxiong Hort.
al. found that mutations in drug-resistant genes can (36) Phragmites australis (Cav.) Trin. ex Steud.
35
prolong fever and cough duration in children with M. (37) Coix lacryma‑jobi L.
pneumoniae, necessitating the addition of tetracyclines
to control further infection development . Despite (38) Benincasa hispida (Thunb.) Cogn.
36
their use, antibiotics have several side effects, including (39) Prunus persica (L.) Batsch
abdominal pain, distension, nausea, vomiting, and other (40) Ziziphus jujuba Mill.
37
gastrointestinal symptoms. Therefore, Western medicine
38
alone cannot fully meet clinical needs. Chen found that and lung function indices in children while reducing the
combining Western medicine with Chinese medicine incidence of adverse reactions. The “lung-intestinal axis”
soup therapy significantly improves cough duration, fever, in modern medicine aligns with the TCM concept of “the

Volume 9 Issue 2 (2025) 51 doi: 10.36922/ejmo.8602