Page 60 - EJMO-9-2

Eurasian Journal of
Medicine and Oncology TCM regulates gut microbiota in pediatric MP pneumonia

Figure 8. Forest plot comparing total clinical effectiveness of Chinese medicine based on gut flora in treatment of mycoplasma pneumonia post-sensitivity analysis
Notes: The effect size is presented as RRs with 95% CIs. The vertical line (RR=1) represents no effect
Abbreviations: CI: Confidence interval; RR: Risk ratio.

Table 3. Prescription and drug composition of Chinese approach to the prevention and treatment of pediatric
medicines included in the study respiratory disorders.
Study ID Herbal prescription Herbal formula The pathogenesis of MPP is primarily associated with
Hua 28 Maxing Shigan Tang (1)(2)(3)(4)(5)(6)(7)(8)(9) immune evasion, adhesion, inflammatory damage, and
Zhong 24 Chinese Herbal Plaster (1)(2)(3)(10)(11) cytotoxicity. M. pneumoniae colonizes the respiratory
Di et al. 27 Xuanfei Tongluo (1)(2)(3)(4)(12)(13)(14) tract through specific adherence organelles. The bacterial
Formula (15)(16)(17) components, metabolites, and toxins released by the
Yang 23 Modified Wuhu Tang (1)(2)(3)(4)(5)(18)(19) organism induce inflammation and damage cells in
(20)(21) various ways, ensuring pathogen survival through immune
39
Bao and Jiang 26 Modified Xuanbai (1)(2)(3)(4)(5)(8)(10)(19) evasion. Consequently, targeted therapy is particularly
40
Chengqi Tang (22)(23) important for managing MPP. Studies have shown that
Huang 18 Maxing Ganshi Tang (1)(2)(3)(4)(22) children with M. pneumoniae have significantly altered
41
Liu 21 Chinese Herbal Plaster (1)(10)(18)(32)(33) intestinal microbiota compared to healthy children. T
Sha 22 Yangyin Qingfei Tang (4)(8)(13)(23)(24)(25)(26) helper (Th) 1 and Th2 cells produce interferon-gamma
(27)(28)(29)(30)(31) (IFN-γ) and serum IL-4, respectively, and regulate each
42
Bao 25 Modified Xuanbai (1)(2)(3)(4)(5)(10)(19)(22) other to maintain normal immune status. In contrast,
Chengqi Tang (23)(34) pneumonia induces elevated levels of IFN-γ and IL-4,
Li and Bai 20 Modified Tingli Dazao (1)(3)(5)(10)(30)(35)(40) which kill inflammatory cells and affect the transcription
Xiefei Tang and secretion of pro-inflammatory cytokines. Hu et al. 43
Ke et al. 19 Modified Qianjin (3)(14)(16)(36)(37)(38)(39) found that the serum levels of IFN-γ and IL-4 in pediatric
Weijing Tang patients with MPP increased as the abundance of intestinal
Note: The numbers in the parentheses can be referred to in Table 2. microbiota decreased. Bifidobacterium bifidum in the
intestinal microbiota can regulate Th1/Th2 and Th17/
lung and large intestine being mutually exclusive,” and regulatory T (Treg) cell balance. By downregulating
their combination can effectively improve the cure rate IL-4 levels, it prevents the activation of the STAT6
and safety of mycoplasma pneumonia. This offers a novel signaling pathway by JAK kinases, thereby enhancing

Volume 9 Issue 2 (2025) 52 doi: 10.36922/ejmo.8602