Page 93 - EJMO-9-2
P. 93

Eurasian Journal of Medicine and
            Oncology
                                                                              Cancer pathway ranking through odds ratios


            Availability of data                                  molecular to clinical aspects. Int J Mol Sci. 2022;23(17):10132.

            Data supporting the findings of this study are available      doi: 10.3390/ijms231710132
            from the corresponding author on reasonable request.  13.  Fadhal E. A  comprehensive analysis of the PI3K/AKT
                                                                  pathway: Unveiling key proteins and therapeutic targets for
             References                                           cancer treatment. Cancer Inform. 2023;22.
            1.   Hanahan D, Weinberg RA. Hallmarks of cancer: The next      doi: 10.1177/11769351231194273
               generation. Cell. 2011;144(5):646-674.
                                                               14.  Hnisz D, Weintraub AS, Day DS, et al. Activation of proto-
               doi: 10.1016/j.cell.2011.02.013                    oncogenes by disruption of chromosome neighborhoods.
            2.   Franceschini A, Szklarczyk D, Frankild S,  et al. STRING   Science. 2016;351(6280):1454-1458.
               v9. 1: Protein-protein interaction networks, with      doi: 10.1126/science.aad9024
               increased coverage and integration.  Nucleic  Acids  Res.
               2012;41(D1):D808-D815.                          15.  Zhang  L,  Guo  Y,  Li  B,  et al.  Identification  of  biomarkers
                                                                  for hepatocellular carcinoma using network-based
               doi: 10.1093/nar/gks1094                           bioinformatics methods. Eur J Med Res. 2013;18:35.
            3.   Hanahan D, Weinberg RA. The hallmarks of cancer. Cell.      doi: 10.1186/2047-783X-18-35
               2000;100(1):57-70.
                                                               16.  Gill R, Datta S, Datta S. A  statistical framework for
               doi: 10.1016/s0092-8674(00)81683-9                 differential network analysis from microarray data.  BMC
            4.   Vogelstein B, Kinzler KW. Cancer genes and the pathways   Bioinformatics. 2010;11:95.
               they control. Nat Med. 2004;10(8):789-799.         doi: 10.1186/1471-2105-11-95
               doi: 10.1038/nm1087                             17.  Fadhal E, Gamieldien J, Mwambene EC. Protein interaction
            5.   Barabási AL, Gulbahce N, Loscalzo J. Network medicine:   networks as metric spaces: A  novel perspective on
               A  network-based approach to human disease.  Nat Rev   distribution of hubs. BMC Syst Biol. 2014;8:6.
               Genet. 2011;12(1):56-68.                           doi: 10.1186/1752-0509-8-6
               doi: 10.1038/nrg2918                            18.  Fadhal E, Mwambene EC, Gamieldien J. Modelling human
            6.   Futreal PA, Coin L, Marshall M, et al. A census of human   protein interaction networks as metric spaces has potential
               cancer genes. Nat Rev Cancer. 2004;4(3):177-183.   in disease research and drug target discovery. BMC Syst Biol.
                                                                  2014;8:68.
               doi: 10.1038/nrc1299
                                                                  doi: 10.1186/1752-0509-8-68
            7.   Jiang N, Dai Q, Su X, Fu J, Feng X, Peng J. Role of PI3K/AKT
               pathway in cancer: The framework of malignant behavior.   19.  Davis AP, Grondin CJ, Johnson RJ,  et al. Comparative
               Mol Biol Rep. 2020;47(6):4587-4629.                toxicogenomics database (CTD): Update 2021. Nucleic Acids
                                                                  Res. 2021;49(D1):D1138-D1143.
               doi: 10.1007/s11033-020-05435-1
                                                                  doi: 10.1093/nar/gkaa891
            8.   Smyth MJ, Johnstone RW. Role of TNF in lymphocyte‐
               mediated cytotoxicity. Microsc Res Tech. 2000;50(3):196-208.  20.  Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S,
                                                                  Diaz LA Jr., Kinzler KW. Cancer genome landscapes. Science.
               doi: 10.1002/1097-0029(20000801)50:3<196:AID-JEMT3>3.0.CO;2-9
                                                                  2013;339(6127):1546-1558.
            9.   Mondal D, Narwani D, Notta S, Ghaffar D, Mardhekar N,      doi: 10.1126/science.1235122
               Quadri SS. Oxidative stress and redox signaling in CRPC
               progression: Therapeutic potential of clinically-tested Nrf2-  21.  Viera AJ. Odds ratios and risk ratios: What’s the difference
               activators. Cancer Drug Resist. 2021;4(1):96-124.  and why does it matter? South Med J. 2008;101(7):730-734.
               doi: 10.20517/cdr.2020.71                          doi: 10.1097/SMJ.0b013e31817a7ee4
            10.  Reya T, Clevers H. Wnt signalling in stem cells and cancer.   22.  Davis AP, Grondin CJ, Johnson RJ, et al. The comparative
               Nature. 2005;434(7035):843-850.                    toxicogenomics database: Update 2019. Nucleic Acids Res.
                                                                  2019;47(D1):D948-D954.
               doi: 10.1038/nature03319
                                                                  doi: 10.1093/nar/gky868
            11.  Hua H, Kong Q, Zhang H, Wang J, Luo T, Jiang Y. Targeting
               mTOR for cancer therapy. J Hematol Oncol. 2019;12:71.  23.  Aggarwal BB. Signalling pathways of the TNF superfamily:
                                                                  A double-edged sword. Nature Rev Immunol. 2003;3(9):745-756.
               doi: 10.1186/s13045-019-0754-1
                                                                  doi: 10.1038/nri1184
            12.  Stanciu S, Ionita-Radu F, Stefani C, et al. Targeting PI3K/
               AKT/mTOR signaling pathway in pancreatic cancer: From   24.  Grivennikov SI, Greten FR, Karin M. Immunity,


            Volume 9 Issue 2 (2025)                         85                              doi: 10.36922/ejmo.8082
   88   89   90   91   92   93   94   95   96   97   98