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Gene & Protein in Disease Photothermal therapy of pentamethine cyanine

not induce colorectal cell death through the photodynamic Availability of data and materials
effect.
Samples of the compounds are available from the authors.
4. Conclusions References

In summary, an asymmetric, water-soluble pentamethine 1. Fakih MG, 2015, Metastatic colorectal cancer: Current state
cyanine derivative CY5-664 with integrated imaging, and future directions. J Clin Oncol, 33: 1809–1824.
targeting, and therapeutic properties has been found in
this work. Significant anti-CRC activity of CY5-664 was https://doi.org/10.1200/JCO.2014.59.7633
observed by the multifunctional photosensitizer through 2. Kuipers EJ, Grady WM, Lieberman D, et al., 2015, Colorectal
cell viability and animal xenograft model experiments. This cancer. Nat Rev Dis Primers, 1: 15065.
multifunctional photosensitizer CY5-664 may have great https://doi.org/10.1038/nrdp.2015.65
application prospects as a safe and effective reagent for
treating CRC because of the following advantages. First, CY5- 3. Bray F, Ferlay J, Soerjomataram I, et al., 2018, Global cancer
statistics 2018: GLOBOCAN estimates of incidence and
664 preferentially accumulates in the tumor as time elapsed, mortality worldwide for 36 cancers in 185 countries. CA
and the maximum fluorescence intensity was observed at Cancer J Clin, 68: 394–424.
24 h. Second, CY5-664 has good water solubility and can be
dissolved in a cell culture medium or NS without DMSO. https://doi.org/10.3322/caac.21492
Third, CY5-664 can be imaged in vivo, which is conducive 4. Dekker E, Tanis PJ, Vleugels JL, et al., 2019, Colorectal
to its application in imaging-guided photosensitive therapy. cancer. Lancet, 394: 1467–1480.
Finally, CY5-664 exhibits significant PTT effects for CRC https://doi.org/10.1016/S0140-6736(19)32319-0
therapy without significant side effects. In brief, this study
not only found a multifunctional photosensitizer CY5-664, 5. Tomasello G, Petrelli F, Ghidini M, et al., 2017, FOLFOXIRI
plus bevacizumab as conversion therapy for patients
but also provided an alternative treatment strategy to develop with initially unresectable metastatic colorectal cancer:
pentamethine cyanine-based CRC theranostic photosensitizer A systematic review and pooled analysis. JAMA Oncol, 3:
for synergistic CRC targeting, imaging, and therapy. e170278.
Acknowledgments https://doi.org/10.1001/jamaoncol.2017.0278

None. 6. Jardim DL, Rodrigues CA, Novis YA, et al., 2012, Oxaliplatin-
related thrombocytopenia. Ann Oncol, 23: 1937–1942.
Funding https://doi.org/10.1093/annonc/mds074

This work was financially supported by the National Natural 7. Fan W, Yung B, Huang P, et al., 2017, Nanotechnology
Science Foundation of China (No. 81803573), China for multimodal synergistic cancer therapy. Chem Rev,
Postdoctoral Science Foundation (No. 2018M640672), 117: 13566–13638.
and Key R&D and Promotion Projects in Henan Province https://doi.org/10.1021/acs.chemrev.7b00258
(No. 222102310013).
8. de Boer E, Harlaar NJ, Taruttis A, et al., 2015, Optical
Conflict of interest innovations in surgery. Br J Surg, 102: e56–72.
https://doi.org/10.1002/bjs.9713
The authors declare no conflict of interest.
9. Liang C, Xu L, Song G, et al., 2016, Emerging nanomedicine
Author contributions approaches fighting tumor metastasis: Animal models,
metastasis-targeted drug delivery, phototherapy, and
Conceptualization: Kun Tang, Shuangshuang Jia, Yaxin immunotherapy. Chem Soc Rev, 45: 6250–6269.
Zou, Jiaheng Dong, and Lei Zhang
Formal analysis: Kun Tang https://doi.org/10.1039/c6cs00458j
Investigation: Shuangshuang Jia, Yaxin Zou, Jiaheng Dong, 10. Zhen X, Cheng P, Pu K, 2019, Recent advances in
Fangyan Liu, Kunli Cui, and Xiao Shi cell membrane-camouflaged nanoparticles for cancer
Methodology: Kun Tang, Shuangshuang Jia, Yaxin Zou, phototherapy. Small, 15: e1804105.
Jiaheng Dong, and Lei Zhang https://doi.org/10.1002/smll.201804105
Writing – original draft: Kun Tang 11. Jung HS, Verwilst P, Sharma A, et al., 2018, Organic molecule-
Writing – review & editing: Lei Zhang based photothermal agents: An expanding photothermal
All the authors read and agreed to publish the version of therapy universe. Chem Soc Rev, 47: 2280–2297.
this study. https://doi.org/10.1039/c7cs00522a

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