Page 101 - GPD-1-2

Gene & Protein in Disease Structure and function of USP7

balances the level of c-Myc ubiquitination and thereby https://doi.org/10.1016/j.celrep.2012.11.011
determines neural stem cell fate specification. Cell Death 34. Hu M, Li P, Li M, et al., 2002, Crystal structure of a UBP-
Differ, 26(4): 728–740. family deubiquitinating enzyme in isolation and in complex
https://doi.org/10.1038/s41418-018-0144-1 with ubiquitin aldehyde. Cell, 111(7): 1041–1054.
23. Zheng N, Chu M, Lin M, et al., 2020, USP7 stabilizes EZH2 https://doi.org/10.1016/s0092-8674(02)01199-6
and enhances cancer malignant progression. Am J Cancer 35. Culig Z, Santer FR, 2014, Androgen receptor signaling in
Res, 10(1): 299–313. prostate cancer. Cancer Metastasis Rev, 33(2-3): 413–427.
24. Li M, Chen D, Shiloh A, et al., 2002, Deubiquitination of p53 https://doi.org/10.1007/s10555-013-9474-0
by HAUSP is an important pathway for p53 stabilization.
Nature, 416(6881): 648–653. 36. Swatek KN, Komander D, 2016, Ubiquitin modifications.
Cell Res, 26(4): 399–422.
https://doi.org/10.1038/nature737
https://doi.org/10.1038/cr.2016.39
25. Tavana O, Gu W, 2017, Modulation of the p53/MDM2
interplay by HAUSP inhibitors. J Mol Cell Biol, 9(1): 45–52. 37. Huang YT, Cheng AC, Tang HC, et al., 2021, USP7 facilitates
SMAD3 autoregulation to repress cancer progression in
https://doi.org/10.1093/jmcb/mjw049 p53-deficient lung cancer. Cell Death Dis, 12(10): 880.

26. Brooks CL, Li M, Hu M, et al., 2007, The p53--Mdm2-- https://doi.org/10.1038/s41419-021-04176-8
HAUSP complex is involved in p53 stabilization by HAUSP.
Oncogene, 26(51): 7262–7266. 38. Jiang S, Wang X, He Y, et al., 2021, Suppression of USP7
induces BCR-ABL degradation and chronic myelogenous
https://doi.org/10.1038/sj.onc.1210531 leukemia cell apoptosis. Cell Death Dis, 12(5):456.
27. Ma J, Martin JD, Xue Y, et al., 2010, C-terminal region of https://doi.org/10.1038/s41419-021-03732-6
USP7/HAUSP is critical for deubiquitination activity and
contains a second mdm2/p53 binding site. Arch Biochem 39. Ji L, Lu B, Zamponi R, et al., 2019, USP7 inhibits Wnt/β-
catenin signaling through promoting stabilization of Axin.
Biophys, 503(2): 207–212.
Nat Commun, 10(1): 4184.
https://doi.org/10.1016/j.abb.2010.08.020
https://doi.org/10.1038/s41467-019-12143-3
28. Komander D, Clague MJ, Urbé S, 2009, Breaking the chains: 40. Lee YR, Chen M, Lee JD, et al., 2019, Reactivation of PTEN
Structure and function of the deubiquitinases. Nat Rev Mol tumor suppressor for cancer treatment through inhibition of a
Cell Biol, 10(8): 550–563.
MYC-WWP1 inhibitory pathway. Science, 364(6441): eaau0159.
https://doi.org/10.1038/nrm2731 https://doi.org/10.1126/science.aau0159
29. Faesen AC, Luna-Vargas MP, Sixma TK, 2012, The role of 41. Wang G, Zhuang Z, Shen S, et al., 2022, Regulation of PTEN
UBL domains in ubiquitin-specific proteases. Biochem Soc and ovarian cancer progression by an E3 ubiquitin ligase
Trans, 40(3): 539–545. RBCK1. Hum Cell, 35(3): 896–908.
https://doi.org/10.1042/BST20120004 https://doi.org/10.1007/s13577-022-00681-w
30. Faesen AC, Dirac AM, Shanmugham A, et al., 2011, 42. He YM, Zhou XM, Jiang SY, et al., 2022, TRIM25
Mechanism of USP7/HAUSP activation by its C-terminal activates AKT/mTOR by inhibiting PTEN via K63-linked
ubiquitin-like domain and allosteric regulation by GMP- polyubiquitination in non-small cell lung cancer. Acta
synthetase. Mol Cell, 44(1): 147–159. Pharmacol Sin, 43(3): 681–691.
https://doi.org/10.1016/j.molcel.2011.06.034 https://doi.org/10.1038/s41401-021-00662-z
31. Kim RQ, van Dijk WJ, Sixma TK, 2016, Structure of USP7 43. Trotman LC, Wang X, Alimonti A, et al., 2007, Ubiquitination
catalytic domain and three Ubl-domains reveals a connector regulates PTEN nuclear import and tumor suppression. Cell,
α-helix with regulatory role. J Struct Biol, 195(1): 11–18. 128(1): 141–156.
https://doi.org/10.1016/j.jsb.2016.05.005 https://doi.org/10.1016/j.cell.2006.11.040
32. van der Knaap JA, Kumar BR, Moshkin YM, et al., 2005, 44. van der Horst A, de Vries-Smits AM, Brenkman AB,
GMP synthetase stimulates histone H2B deubiquitylation et al., 2006, FOXO4 transcriptional activity is regulated by
by the epigenetic silencer USP7. Mol Cell, 17(5): 695–707. monoubiquitination and USP7/HAUSP. Nat Cell Biol, 8(10):
https://doi.org/10.1016/j.molcel.2005.02.013 1064–1073.
33. Cotto-Rios XM, Békés M, Chapman J, et al., 2012, https://doi.org/10.1038/ncb1469
Deubiquitinases as a signaling target of oxidative stress. Cell 45. Qian J, Pentz K, Zhu Q, et al., 2015, USP7 modulates
Rep, 2(6): 1475–1484. UV-induced PCNA monoubiquitination by regulating DNA

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