Page 105 - GPD-1-2
P. 105
Gene & Protein in Disease Structure and function of USP7
43(2): e20190338. USP7: Implications for the regulation of the p53-MDM2
pathway. PLoS Biol, 4(2): e27.
https://doi.org/10.1590/1678-4685-GMB-2019-0338
https://doi.org/10.1371/journal.pbio.0040027
109. Khoronenkova SV, Dianov GL, 2013, USP7S-dependent
inactivation of Mule regulates DNA damage signalling and 121. Sheng Y, Saridakis V, Sarkari F, et al., 2006, Molecular
repair. Nucleic Acids Res, 41(3): 1750–1756. recognition of p53 and MDM2 by USP7/HAUSP. Nat Struct
https://doi.org/10.1093/nar/gks1359 Mol Biol, 13(3): 285–291.
110. Zhu Q, Sharma N, He J, et al., 2015, USP7 deubiquitinase https://doi.org/10.1038/nsmb1067
promotes ubiquitin-dependent DNA damage signaling by 122. Cummins JM, Rago C, Kohli M, et al., 2004, Tumour
stabilizing RNF168. Cell Cycle, 14(9): 1413–1425. suppression: Disruption of HAUSP gene stabilizes p53.
Nature, 428(6982):1 p following 486.
https://doi.org/10.1080/15384101.2015.1007785
111. Ni W, Lin S, Bian S, et al., 2020, USP7 mediates pathological https://doi.org/10.1038/nature02501
hepatic de novo lipogenesis through promoting stabilization 123. Ali A, Raja R, Farooqui SR, et al., 2017, USP7 deubiquitinase
and transcription of ZNF638. Cell Death Dis, 11(10): 843. controls HIV-1 production by stabilizing Tat protein.
112. Franqui-Machin R, Hao M, Bai H, et al., 2018, Destabilizing Biochem J, 474(10): 1653–1668.
NEK2 overcomes resistance to proteasome inhibition in https://doi.org/10.1042/BCJ20160304
multiple myeloma. J Clin Invest, 128(7): 2877–2893.
124. Gao L, Zhu D, Wang Q, et al., 2021, Proteome analysis of
https://doi.org/10.1172/JCI98765 USP7 substrates revealed its role in melanoma through
113. Kim JM, Yang YS, Park KH, et al., 2020, A RUNX2 PI3K/Akt/FOXO and AMPK pathways. Front Oncol,
stabilization pathway mediates physiologic and pathologic 11: 650165.
bone formation. Nat Commun, 11(1): 2289. https://doi.org/10.3389/fonc.2021.650165
https://doi.org/10.1038/s41467-020-16038-6 125. Yao Y, Zhang Y, Shi M, et al., 2018, Blockade of deubiquitinase
114. Ma P, Yang X, Kong Q, et al., 2014, The ubiquitin ligase USP7 overcomes bortezomib resistance by suppressing
RNF220 enhances canonical Wnt signaling through USP7- NF-κB signaling pathway in multiple myeloma. J Leukoc
mediated deubiquitination of β-catenin. Mol Cell Biol, Biol, 104(6): 1105–1115.
34(23): 4355–4366. https://doi.org/10.1002/JLB.2A1017-420RR
https://doi.org/10.1128/MCB.00731-14 126. Cai J, Chen HY, Peng SJ, et al., 2018, USP7-TRIM27 axis
115. Jang SY, Jang SW, Ko J, 2012, Regulation of ADP-ribosylation negatively modulates antiviral type I IFN signaling. Faseb J,
factor 4 expression by small leucine zipper protein and 32(10): 5238–5249.
involvement in breast cancer cell migration. Cancer Lett, https://doi.org/10.1096/fj.201700473RR
314(2): 185–197.
127. Colleran A, Collins PE, O’Carroll C, et al., 2013, Deubiquitination
https://doi.org/10.1016/j.canlet.2011.09.028 of NF-κB by ubiquitin-specific protease-7 promotes
116. Hofseth LJ, Hussain SP, Harris CC, 2004, p53: 25 years after transcription. Proc Natl Acad Sci U S A, 110(2): 618–623.
its discovery. Trends Pharmacol Sci, 25(4): 177–181. https://doi.org/10.1073/pnas.1208446110
https://doi.org/10.1016/j.tips.2004.02.009 128. Zeng M, Zhang X, Xing W, et al., 2022, Cigarette smoke
117. Sabapathy K, Lane DP, 2018, Therapeutic targeting of p53: extract mediates cell premature senescence in chronic
All mutants are equal, but some mutants are more equal obstructive pulmonary disease patients by up-regulating
than others. Nat Rev Clin Oncol, 15(1): 13–30. USP7 to activate p300-p53/p21 pathway. Toxicol Lett,
359: 31–45.
https://doi.org/10.1038/nrclinonc.2017.151
https://doi.org/10.1016/j.toxlet.2022.01.017
118. Kruse JP, Gu W, 2009, Modes of p53 regulation. Cell, 137(4):
609–622. 129. Duan D, Shang M, Han Y, et al., 2022, EZH2-CCF-cGAS Axis
Promotes Breast Cancer Metastasis. Int J Mol Sci, 23(3): 1788.
https://doi.org/10.1016/j.cell.2009.04.050
https://doi.org/10.3390/ijms23031788
119. Momand J, Zambetti GP, Olson DC, et al., 1992, The mdm-2
oncogene product forms a complex with the p53 protein and 130. Qi SM, Cheng G, Cheng XD, et al., 2020, Targeting USP7-
inhibits p53-mediated transactivation. Cell, 69(7): 1237–1245. mediated deubiquitination of MDM2/MDMX-p53 pathway
for cancer therapy: Are we there yet? Front Cell Dev Biol, 8: 233.
https://doi.org/10.1016/0092-8674(92)90644-r
https://doi.org/10.3389/fcell.2020.00233
120. Hu M, Gu L, Li M, et al., 2006, Structural basis of
competitive recognition of p53 and MDM2 by HAUSP/ 131. Cheng X, Zhang B, Guo F, et al., 2022, Deubiquitination
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