Page 103 - GPD-1-2
P. 103
Gene & Protein in Disease Structure and function of USP7
apoptotic pathway. Mol Cell Biol, 33(16): 3309–3320. insulin-like growth factor (IGF) stimulation abrogates an
association between a deubiquitinating enzyme USP7 and
https://doi.org/10.1128/MCB.00358-13
insulin receptor substrates (IRSs) followed by proteasomal
68. Das S, Chandrasekaran AP, Jo KS, et al., 2020, HAUSP degradation of IRSs. Biochem Biophys Res Commun, 423(1):
stabilizes Cdc25A and protects cervical cancer cells from 122–127.
DNA damage response. Biochim Biophys Acta Mol Cell Res,
1867(12): 118835. https://doi.org/10.1016/j.bbrc.2012.05.093
79. Sarkari F, Wheaton K, La Delfa A, et al., 2013, Ubiquitin-
https://doi.org/10.1016/j.bbamcr.2020.118835
specific protease 7 is a regulator of ubiquitin-conjugating
69. Qing P, Han L, Bin L, et al., 2011, USP7 regulates the stability enzyme UbE2E1. J Biol Chem, 288(23): 16975–16985.
and function of HLTF through deubiquitination. J Cell
Biochem, 112(12): 3856–3862. https://doi.org/10.1074/jbc.M113.469262
80. Bhattacharya S, Ghosh MK, 2015, HAUSP regulates c-MYC
https://doi.org/10.1002/jcb.23317
expression via de-ubiquitination of TRRAP. Cell Oncol
70. Zemp I, Lingner J, 2014, The shelterin component TPP1 (Dordr), 38(4): 265–277.
is a binding partner and substrate for the deubiquitinating https://doi.org/10.1007/s13402-015-0228-6
enzyme USP7. J Biol Chem, 289(41): 28595–28606.
81. Li N, Zhao Z, Liu P, et al., 2021, Upregulation of
https://doi.org/10.1074/jbc.M114.596056
deubiquitinase USP7 by transcription factor FOXO6
71. Galarreta A, Valledor P, Ubieto-Capella P, et al., 2021, USP7 promotes EC progression via targeting the JMJD3/CLU axis.
limits CDK1 activity throughout the cell cycle. Embo J, Mol Ther Oncolytics, 20: 583–595.
40(11): e99692.
https://doi.org/10.1016/j.omto.2020.12.008
https://doi.org/10.15252/embj.201899692
82. Episkopou H, Diman A, Claude E, et al., 2019, TSPYL5
72. Holowaty MN, Sheng Y, Nguyen T, et al., 2003, Protein depletion induces specific death of ALT cells through USP7-
interaction domains of the ubiquitin-specific protease, dependent proteasomal degradation of POT1. Mol Cell,
USP7/HAUSP. J Biol Chem, 278(48): 47753–47761. 75(3): 469–482.e466.
https://doi.org/10.1074/jbc.M307200200 https://doi.org/10.1016/j.molcel.2019.05.027
73. Zhao XB, Ji FY, Li HR, et al., 2020, P22077 inhibits LPS- 83. Felle M, Joppien S, Németh A, et al., 2011, The USP7/Dnmt1
induced inflammatory response by promoting K48-linked complex stimulates the DNA methylation activity of Dnmt1
ubiquitination and degradation of TRAF6. Aging (Albany and regulates the stability of UHRF1. Nucleic Acids Res,
NY), 12(11): 10969–10982. 39(19): 8355–8365.
https://doi.org/10.18632/aging.103309 https://doi.org/10.1093/nar/gkr528
74. Alonso-de Vega I, Martín Y, Smits VA, 2014, USP7 controls 84. Zhu Q, Ding N, Wei S, et al., 2020, USP7-mediated
Chk1 protein stability by direct deubiquitination. Cell Cycle, deubiquitination differentially regulates CSB but not UVSSA
13(24): 3921–3926. upon UV radiation-induced DNA damage. Cell Cycle, 19(1):
124–141.
https://doi.org/10.4161/15384101.2014.973324
https://doi.org/10.1080/15384101.2019.1695996
75. Daubeuf S, Singh D, Tan Y, et al., 2009, HSV ICP0 recruits
USP7 to modulate TLR-mediated innate response. Blood, 85. Lu X, Zhang Y, Zheng Y, et al., 2021, The miRNA-15b/USP7/
113(14): 3264–3275. KDM6B axis engages in the initiation of osteoporosis by
modulating osteoblast differentiation and autophagy. J Cell
https://doi.org/10.1182/blood-2008-07-168203
Mol Med, 25(4): 2069–2081.
76. Spardy N, Covella K, Cha E, et al., 2009, Human https://doi.org/10.1111/jcmm.16139
papillomavirus 16 E7 oncoprotein attenuates DNA damage
checkpoint control by increasing the proteolytic turnover of 86. Lee KW, Cho JG, Kim CM, et al., 2013, Herpesvirus-
claspin. Cancer Res, 69(17): 7022–7029. associated ubiquitin-specific protease (HAUSP) modulates
peroxisome proliferator-activated receptor γ (PPARγ)
https://doi.org/10.1158/0008-5472.CAN-09-0925
stability through its deubiquitinating activity. J Biol Chem,
77. Zaman MM, Nomura T, Takagi T, et al., 2013, Ubiquitination- 288(46): 32886–32896.
deubiquitination by the TRIM27-USP7 complex regulates
tumor necrosis factor alpha-induced apoptosis. Mol Cell https://doi.org/10.1074/jbc.M113.496331
Biol, 33(24): 4971–4984. 87. Salsman J, Jagannathan M, Paladino P, et al., 2012, Proteomic
profiling of the human cytomegalovirus UL35 gene products
https://doi.org/10.1128/MCB.00465-13
reveals a role for UL35 in the DNA repair response. J Virol,
78. Yoshihara H, Fukushima T, Hakuno F, et al., 2012, Insulin/ 86(2): 806–820.
Volume 1 Issue 2 (2022) 13 https://doi.org/10.36922/gpd.v1i2.118

