Page 48 - GPD-1-2

Gene & Protein in Disease

REVIEW ARTICLE
Differential expression profiles of circRNAs

in cancers: Future clinical and diagnostic
perspectives

1
2,4
Faiz Ali Khan 1,2,3 , Bernard Nsengimana , Nazeer Hussain Khan , Jingjing Huang ,
1
1
1
Haojie Guo , Usman Ayub Awan , Weijuan Zhang *, Wenqiang Wei *, and Shaoping Ji *
1
1
5
1 Laboratory of Cell Signal Transduction, Department of Biochemistry and Molecular Biology, School
of Basic Medical Sciences, Henan University, Kaifeng, China
2 School of Life Sciences, Henan University, Kaifeng, China
3 Department of Basic Sciences Research, Shaukat Khanum Memorial Cancer Hospital and Research
Centre (SKMCH&RC), Lahore, Pakistan
4 Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical
Sciences, Henan University, Kaifeng, Henan, China
5 Department of Medical Laboratory Technology, The University of Haripur, Haripur, Khyber
Pakhtunkhwa, Pakistan

Abstract

Since decades ago, circular RNAs (circRNAs) have been known for their critical role
in RNA maturation, RNA transportation, epigenetic regulation, gene transcription,
*Corresponding authors: peptide/protein translation, and interaction with proteins to modulate their activities.
Weijuan Zhang At present, circRNAs are being extensively studied as oncotargets in the onset and
(zwjuan1965@henu.edu.cn)
Wenqiang Wei development of several malignancies and treatment resistance by modulating various
(weiwq@henu.edu.cn) signaling pathways and cellular processes such as ubiquitination, degradation,
Shaoping Ji invasion, proliferation, c-Myc oncoprotein stabilization, epithelial-mesenchymal
(shaopingji@henu.edu.cn)
transition, autophagy, and apoptosis. In addition, circRNAs are known to be highly
Citation: Khan FA, Nsengimana B, conserved, have a longer life span than other RNAs, and their differential expressions
Khan NH, et al., 2022, Differential
expression profiles of circRNAs are implicated in solid tumors and hematological malignancies. However, their
in cancers: Future clinical and potential diagnostic and therapeutic targets are not fully elucidated. Therefore, we
diagnostic perspectives. Gene sought to underline the opportunities and constraints associated with using these
Protein Dis, 1(2):138.
https://doi.org/10.36922/gpd. oncotargets in cancer therapy by outlining the functional mechanisms of circRNAs
v1i2.138 and their ectopic expression in distinct malignancies. The clinical applications of
circRNAs in developing progressive markers like liquid biopsy biomarkers and for
Received: June 18, 2022
Accepted: September 27, 2022 treating cancers are also prospected in this paper.
Published Online: October 20, 2022
Copyright: © 2022 Author(s). Keywords: CircRNAs; Upregulation; Down-regulation; Anticancer drugs resistance; Liquid
This is an Open-Access article
distributed under the terms of the biopsy biomarkers
Creative Commons Attribution
License, permitting distribution,
and reproduction in any medium,
provided the original work is
properly cited. 1. Introduction
Publisher’s Note: AccScience Circular RNAs (circRNAs) are among the most thoroughly investigated ncRNAs
Publishing remains neutral with in recent years, accounting for most of the human non-coding transcriptome [1,2] .
regard to jurisdictional claims in
published maps and institutional Subsequent research has recognized the importance of circRNAs in regulating many
affiliations. cellular developmental and biological events, which involve critical molecular processes

Volume 1 Issue 2 (2022) 1 https://doi.org/10.36922/gpd.v1i2.138