Page 55 - GPD-1-2

Gene & Protein in Disease circRNAs and cancer

Table 1. circRNAs dysregulated in several cancers and also found in body fluids.
Cancer circRNA Expression Body Function Pathway/ Pathological status Cases/ References
type in disease fluid miRNA sponge controls
BC hsa_ Up Plasma The expression level decreases - Associated with 57/17 [124]
circ_0001785 significantly in post-operative histological grade,
patients than pre-operative TNM stage, and DS
patients. A potential biomarker
for early detection of BC
TC hsa_ Up Serum Potential diagnostic, PI3K-Akt and - 3/3 [125]
circ_007293, exosomes prognostic, or therapeutic AMPK signaling
hsa_ biomarkers pathway
circ_031752,
and hsa_
circ_020135
OC circMAN1A2 Up Serum Could be a good diagnostic miR-135a-3p - 36/121 [126]
biomarker for malignant tumor
hsa_ Up Serum Non-invasive biomarker for the miR-28-5p - 95/53 [127]
circ_0001068 exosomes diagnosis and treatment of OC
EC hsa_ Up Serum EVs circRNAs served as Involved - 10/10 [128]
circ_0109046 biomarkers for EC diagnosis in multiple
& hsa_ pathways
circ_0002577
CRC circIFT80 Up Serum Promotes CRC cell growth, circIFT80/miR- Associated with 58/58 [123]
exosomes proliferation, migration, and 1236-3p/HOXB7 advanced tumor stage
invasion and DS
hsa_ Down Serum A potential biomarker for - Associated with 64/64 [129]
circ_0001649 CRC patients pathological
differentiation
circVAPA Up Plasma Promotes cell proliferation, miR-101/KEGG Associated with 60/60 [130]
migration, invasion, and pathway LNM, DS, and TNM
inhibit apoptosis stage
circFMN2 Up Serum Promotes cell proliferation and circFMN2/miR- Associated with 88/88 [122]
exosomes migration 1182/hTERT tumor size, advanced
tumor stage, DS, and
TNM stage
circ-CCDC66, Down Plasma Promotes tumor growth and - No association 45/61 [131]
circ-ABCC1 progression observed
and circ-STIL
hsa_ Up Serum Associated with - Associated with DS 110/70 [132]
circ_0004771 clinicopathological factors of and TNM stage
GC patients
GC hsa_ Down Plasma Associated with - Associated with tumor 104/014 [51]
circ_0000190 clinicopathological factors of diameter, LNM, DS,
GC patients and TNM stage
hsa_ Down Plasma Might be a novel potential Bind to various Associated with 60/60 [133]
circ_0000745 biomarker for diagnosing of GC miRNAs TNM stage
hsa_ Down Plasma Associated with pathological - Associated with 121/121 [134]
circ_0001017, factors and predictor for early higher mortality and
hsa_ diagnosis, prognosis of GC TNM stage
circ_0061276
hsa_ Up Plasma Promotes proliferation, Bind to various Associated with 51/51 [136]
circ_0000467 migration, and invasion miRNAs TNM stage
LC circFARSA Up Plasma Promotes cell migration and miR-330-5p and No significant 10/10 [91]
invasion miR-326 differences observed
(Cont’d...)

Volume 1 Issue 2 (2022) 8 https://doi.org/10.36922/gpd.v1i2.138