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Gene & Protein in Disease circRNAs and cancer

Table 1. (Continued).
Cancer circRNA Expression Body Function Pathway/ Pathological status Cases/ References
type in disease fluid miRNA sponge controls
UCB circPRMT5 Up Serum Promotes metastasis and Promotes EMT Associated with 119/119 [137]
and urine aggressiveness of USB cells via circPRMT5/ advanced tumor stage
exosomes miR-30c/SNAIL1/ and worse patient
E-cadherin survival
NPC circMAN1A2 Up Serum Could be good diagnostic miR-135a-3p - 100/121 [126]
biomarker for malignant tumor
hsa_ Up Serum Possibly regulates cell miR124 Associated with 150/100 [138]
circ_0000285 proliferation, metastasis, and tumor size,
radio sensitivity differentiation, LNM,
DS, and TNM stage
ALL circPVT1 Up BM Promotes proliferation and Through c-Myc No significant 48/40 [139]
apoptosis and Bcl-2 differences observed
expression in ALL
CLL circ-COX2 Up Plasma Promotes CLL progression - - 54/40 [140]
exosomes and prognosis
MM circMYC Up Exosomes Expression level circMYC - Associated with 122/54 [141]
associated with deletion 17p higher relapse and
mortality rates
hsa_ Up BM Promote cell proliferation, cell Through the - 41/41 [142]
circ_0007841 plasma cycle, metastasis, and inhibits activation
apoptosis of PI3K/Akt
signaling through
miR-338-3p/
BRD4 axis
HCC circSMARCA5 Down Plasma Promotes proliferation, - Associated with 133/33 [143]
invasion, metastasis, and tumor differentiation
inhibits apoptosis and TNM stage
circ-DB Up Plasma Promotes rapid tumor miR-34a/ - - [144]
progression by targeting USP7/ Cyclin
deubiquitination-related A2 signaling
USP7 pathway
circUHRF1 Up Plasma Decreases NK cell proportion Through Associated with 240/240 [145]
and NK cell tumor infiltration degradation of tumor size
and associated with poor miR-449c-5p/
prognosis TIM-3
PC circ- Up Plasma Associated with venous, - No association found 31/31 [146]
LDLRAD3 lymphatic invasion, and with pathological
metastasis factors
OSCC hsa_ Up Salivary The expression level decreases miR-107 and Associated with 163/85 [147]
circ_0001874, in the post-operative samples miR-103a-3p TNM stage and
hsa_ than pre-operative samples tumor grade
circ_0001971,
OS hsa_ Up Serum High expression level - Associated with 50/50 [148]
circ_0000885 associated with lower rates Enneking stage IIB or
of disease-free survival and III osteosarcoma and
overall survival lung metastasis
LAC hsa_ Up Plasma Promotes cell proliferation miR-134 Associated with 49/49 [149]
circ_0013958 and invasion and inhibited cell TNM stage and LNM
apoptosis
BC: Breast cancer; TNM: Tumor node metastasis; DS: Distant metastasis; LNM: Lymph node metastasis; TC: Thyroid cancer; OC: Ovarian cancer;
EC: Endometrial cancer; EVs: Extracellular vesicles; CRC: Colorectal cancer; GC: Gastric cancer; LC: Lung cancer; UCB: Urothelial carcinoma of the
bladder; NPC: Nasopharyngeal carcinoma; ALL: Acute lymphoblastic leukemia; BM: Bone marrow; CLL: Chronic lymphocytic leukemia; MM: Multiple
myeloma; HCC: Hepatocellular carcinoma; PC: Pancreatic cancer; OSCC: Oral squamous cell carcinoma; OS: Osteosarcoma; LAC: Lung adenocarcinoma

Volume 1 Issue 2 (2022) 9 https://doi.org/10.36922/gpd.v1i2.138